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Target
Signal transducer and activator of transcription 1
Ligand
BDBM50353441
Substrate
n/a
Meas. Tech.
ChEMBL_769117 (CHEMBL1832674)
Ki
>25000±n/a nM
Citation
 Page, BD; Fletcher, S; Yue, P; Li, Z; Zhang, X; Sharmeen, S; Datti, A; Wrana, JL; Trudel, S; Schimmer, AD; Turkson, J; Gunning, PT Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain. Bioorg Med Chem Lett 21:5605-9 (2011) [PubMed]  Article
Target
Name:
Signal transducer and activator of transcription 1
Synonyms:
STAT1_MOUSE | Stat1
Type:
PROTEIN
Mol. Mass.:
87184.30
Organism:
Mus musculus
Description:
ChEMBL_863014
Residue:
749
Sequence:
MSQWFELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIYNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEQEIKTLEELQDEYDFKCKTSQNREGEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQTWFTIVAETLQQIRQQLKKLEELEQKFTYEPDPITKNKQVLSDRTFLLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKSRLLVKLQESNLLTKVKCHFDKDVNEKNTVKGFRKFNILGTHTKVMNMEESTNGSLAAELRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKNDLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEMSRIVGPEFDSMMSTV
  
Inhibitor
Name:
BDBM50353441
Synonyms:
CHEMBL1829786
Type:
Small organic molecule
Emp. Form.:
C30H34N2O6S
Mol. Mass.:
550.666
SMILES:
CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(C)cc1
Structure:
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