Reaction Details  Report a problem with these data
Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50187665
Substrate
n/a
Meas. Tech.
ChEMBL_504440 (CHEMBL986727)
IC50
>30000±n/a nM
Citation
 Morikawa, T; Kishi, A; Pongpiriyadacha, Y; Matsuda, H; Yoshikawa, M Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis. J Nat Prod 66:1191-6 (2003) [PubMed]  Article
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50187665
Synonyms:
(-)-epigallocatechin | CHEMBL47386
Type:
Small organic molecule
Emp. Form.:
C15H14O7
Mol. Mass.:
306.2675
SMILES:
O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1 |r|
Structure:
Search PDB for entries with ligand similarity: