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Target
Histamine H4 receptor
Ligand
BDBM189352
Substrate
n/a
Meas. Tech.
In vitro [3H]histamine Binding Assay
pH
7.4±n/a
Temperature
277.15±n/a K
Ki
5.6e+3± 1.32e+3 nM
Comments
extracted
Citation
 Latacz, G; Kechagioglou, P; Papi, R; Lazewska, D; Wiecek, M; Kaminska, K; Wencel, P; Karcz, T; Schwed, JS; Stark, H; Kyriakidis, DA; Kiec-Kononowicz, K The Synthesis of 1,3,5-triazine Derivatives and JNJ7777120 Analogues with Histamine H4 Receptor Affinity and Their Interaction with PTEN Promoter. Chem Biol Drug Des 88:254-63 (2016) [PubMed]  Article
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM189352
Synonyms:
4-(4-Methylpiperazin-1-yl)-6-(naphthalen-1-ylmethyl)-1,3,5-triazin-2-amine (12)
Type:
Small organic molecule
Emp. Form.:
C19H22N6
Mol. Mass.:
334.4182
SMILES:
CN1CCN(CC1)c1nc(N)nc(Cc2cccc3ccccc23)n1
Structure:
Search PDB for entries with ligand similarity: