Reaction Details  Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM489594
Substrate
n/a
Meas. Tech.
Radiolabel Binding Assay
IC50
2.40±n/a nM
Citation
 Blass, BE; Canney, DJ; Blattner, KM Modulators of the sigma-2 receptor and their method of use US Patent  US10961249 Publication Date 3/30/2021
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM489594
Synonyms:
US10961249, Entry 5 | US11220505, Entry 3
Type:
Small organic molecule
Emp. Form.:
C26H38N2O2
Mol. Mass.:
410.5921
SMILES:
CC(C)c1ccccc1N1CC2CN(CCC3CC4(CCCCC4)C(=O)O3)CC2C1
Structure:
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