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Target
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Ligand
BDBM317462
Substrate
n/a
Meas. Tech.
ChEBML_1681482
IC50
136±n/a nM
Citation
 Riggs, JR; Nagy, M; Elsner, J; Erdman, P; Cashion, D; Robinson, D; Harris, R; Huang, D; Tehrani, L; Deyanat-Yazdi, G; Narla, RK; Peng, X; Tran, T; Barnes, L; Miller, T; Katz, J; Tang, Y; Chen, M; Moghaddam, MF; Bahmanyar, S; Pagarigan, B; Delker, S; LeBrun, L; Chamberlain, PP; Calabrese, A; Canan, SS; Leftheris, K; Zhu, D; Boylan, JF The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. J Med Chem 60:8989-9002 (2017) [PubMed]  Article
Target
Name:
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Synonyms:
PHKG | PHKG1 | PHKG1_HUMAN | Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform | Phosphorylase kinase | Phosphorylase kinase gamma subunit 1 | Phosphorylase kinase subunit gamma 1
Type:
PROTEIN
Mol. Mass.:
45025.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774515
Residue:
387
Sequence:
MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFSPRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPKAVLLSLAEEDY
  
Inhibitor
Name:
BDBM317462
Synonyms:
4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2- ylamino)-3-methoxy-N- methylbenzamide | US9623028, Compound 38
Type:
Small organic molecule
Emp. Form.:
C28H28N6O4
Mol. Mass.:
512.5597
SMILES:
CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(OC)c1
Structure:
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