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Target
Glucokinase regulatory protein
Ligand
BDBM50500199
Substrate
n/a
Meas. Tech.
ChEMBL_1545293 (CHEMBL3751186)
Kd
800±n/a nM
Citation
 Pennington, LD; Bartberger, MD; Croghan, MD; Andrews, KL; Ashton, KS; Bourbeau, MP; Chen, J; Chmait, S; Cupples, R; Fotsch, C; Helmering, J; Hong, FT; Hungate, RW; Jordan, SR; Kong, K; Liu, L; Michelsen, K; Moyer, C; Nishimura, N; Norman, MH; Reichelt, A; Siegmund, AC; Sivits, G; Tadesse, S; Tegley, CM; Van, G; Yang, KC; Yao, G; Zhang, J; Lloyd, DJ; Hale, C; St Jean, DJ Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N ? S (nN ? ?*S-X) Interaction for Conformational Constraint. J Med Chem 58:9663-79 (2015) [PubMed]  Article
Target
Name:
Glucokinase regulatory protein
Synonyms:
GCKR_RAT | Gckr | Glucokinase regulator
Type:
PROTEIN
Mol. Mass.:
68920.17
Organism:
Rattus norvegicus
Description:
ChEMBL_108045
Residue:
627
Sequence:
MPGTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVKLLGQCDAEIFQEEGQIVPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREQTEDSALHGIEELKKVAAGKKRVVVIGISVGLSAPFVAGQMDYCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSGSSRMKGGGATKILLETLLLAAHKTVDQGVVSSQRCLLEILRTFERAHQVTYSQSSKIATLMKQVGISLEKKGRVHLVGWQTLGIIAIMDGVECIHTFGADFQDIRGFLIGDHSDMFNQKDELTNQGPQFTFSQDDFLTSILPSLTETDTVVFIFTLDDNLTEVQALAERVREKCQNIQALVHSTVGQSLPAPLKKLFPSLISITWPLLFFDYEGTYVQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRIANSKLFWRALAMLQRFSGQSKARCIESLLQAIHFPQPLSDDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSISEAKARLSAASSVCEVVRSALSGPGQKRSTQALEDPPACGTLN
  
Inhibitor
Name:
BDBM50500199
Synonyms:
CHEMBL3747490
Type:
Small organic molecule
Emp. Form.:
C26H22ClF3N2O3S2
Mol. Mass.:
567.043
SMILES:
C[C@](O)(c1ccnc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1ccccc1Cl)C(F)(F)F |r|
Structure:
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