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Target
Beta-lactamase TEM
Ligand
BDBM50339145
Substrate
n/a
Meas. Tech.
ChEMBL_2108469 (CHEMBL4817144)
IC50
1.9±n/a nM
Citation
 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-?-lactamases. Bioorg Med Chem Lett 41:0 (2021) [PubMed]  Article
Target
Name:
Beta-lactamase TEM
Synonyms:
BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla
Type:
Enzyme
Mol. Mass.:
31512.33
Organism:
Escherichia coli
Description:
P62593
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM50339145
Synonyms:
CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octan-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C7H11N3O6S
Mol. Mass.:
265.244
SMILES:
NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(O)(=O)=O |r|
Structure:
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