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Target
Purine nucleoside phosphorylase
Ligand
BDBM50042800
Substrate
n/a
Meas. Tech.
ChEMBL_162036 (CHEMBL766676)
IC50
47±n/a nM
Citation
 Erion, MD; Niwas, S; Rose, JD; Ananthan, S; Allen, M; Secrist, JA; Babu, YS; Bugg, CE; Guida, WC; Ealick, SE Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group. J Med Chem 36:3771-83 (1994) [PubMed]
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50042800
Synonyms:
2-Amino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL299952
Type:
Small organic molecule
Emp. Form.:
C13H18N4O
Mol. Mass.:
246.3082
SMILES:
Nc1nc2c(CC3CCCCC3)c[nH]c2c(=O)[nH]1
Structure:
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