The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 10340605 |
5 |
Synthesis and evaluation of geldanamycin-estradiol hybrids. |
Sloan-Kettering Institute For Cancer Research |
| 25799158 |
6 |
Volume of Distribution in Drug Design. |
Pharmacokinetics |
| 16854066 |
44 |
Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. |
Infinity Pharmaceuticals |
| 16621545 |
6 |
Synthesis of Hsp90 dimerization modulators. |
Memorial Sloan-Kettering Cancer Center |
| 16530412 |
13 |
High-throughput screening for Hsp90 ATPase inhibitors. |
The University of Kansas |
| 16480864 |
38 |
4-Amino derivatives of the Hsp90 inhibitor CCT018159. |
Vernalis |
| 15828828 |
136 |
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90. |
Memorial Sloan-Kettering Cancer Center |
| 15239664 |
92 |
Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90. |
Conforma Therapeutics |
| 14698151 |
14 |
Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures. |
Ribotargets |
| 14592488 |
2 |
Synthesis of novel fluorescent probes for the molecular chaperone Hsp90. |
Memorial Sloan-Kettering Cancer Center |
| 32305165 |
72 |
Discovery of novel heat shock protein (Hsp90) inhibitors based on luminespib with potent antitumor activity. |
Seoul National University |
| 32222339 |
5 |
Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities. |
Fujian Medical University (Fmu) |
| 32832020 |
1 |
From Bacteria to Cancer: A Benzothiazole-Based DNA Gyrase B Inhibitor Redesigned for Hsp90 C-Terminal Inhibition. |
The University of Notre Dame |
| 32527461 |
1 |
Enzymatic biosynthesis and biological evaluation of novel 17-AAG glucoside as potential anti-cancer agents. |
Bengbu Medical College |
| 32324396 |
17 |
p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. |
China Pharmaceutical University |
| 26844689 |
22 |
Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions. |
Chinese Academy of Sciences |
| 30597326 |
50 |
High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity. |
Jiangsu Normal University |
| 31663736 |
15 |
Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions. |
China Pharmaceutical University |
| 31469962 |
122 |
Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors. |
Korea University |
| 31935086 |
19 |
Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer. |
China Pharmaceutical University |
| 30769242 |
14 |
Clinical candidates modulating protein-protein interactions: The fragment-based experience. |
Taros Chemicals |
| 31188592 |
39 |
Why Some Targets Benefit from beyond Rule of Five Drugs. |
Boston University |
| 30048133 |
1 |
Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design. |
Istituto Di Chimica Del Riconoscimento Molecolare |
| 31519378 |
1 |
C-terminal modulators of heat shock protein of 90?kDa (HSP90): State of development and modes of action. |
Heinrich Heine University D£Sseldorf |
| 27818030 |
5 |
Optimization and bioevaluation of Cdc37-derived peptides: An insight into Hsp90-Cdc37 protein-protein interaction modulators. |
China Pharmaceutical University |
| 25141341 |
1 |
Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors. |
Montclair State University |
| 23859777 |
5 |
Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors. |
University of Arizona |
| 23520985 |
12 |
Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening. |
Universit£ |
| 23606927 |
11 |
3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues. |
The University of Kansas |
| 22877636 |
60 |
Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90. |
Exelixis |
| 22913511 |
91 |
Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor. |
Myrexis |
| 21486005 |
3 |
Gambogic acid, a natural product inhibitor of Hsp90. |
Oklahoma State University |
| 21612924 |
10 |
Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone. |
Pfizer |
| 20718493 |
29 |
Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency. |
Astex Therapeutics |
| 20655237 |
8 |
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors. |
Universit£ |
| 20570149 |
4 |
Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues. |
The University of Kansas |
| 19908836 |
11 |
Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone. |
Pfizer |
| 19395259 |
28 |
Discovery of 5-substituted 2-amino-4-chloro-8-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6(5H)-ones as potent and selective Hsp90 inhibitors. |
Poniard Pharmaceuticals |
| 19552433 |
49 |
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents. |
Serenex |
| 18929486 |
41 |
Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone. |
Pfizer |
| 19101151 |
34 |
Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold. |
The University of Kansas |
| 18762423 |
20 |
Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay. |
Emory University |
| 18571929 |
45 |
Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling. |
Emory University |
| 18020309 |
1 |
Derrubone, an inhibitor of the Hsp90 protein folding machinery. |
The University of Kansas |
| 29545103 |
27 |
Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90). |
National University of Singapore |
| 29701469 |
52 |
Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors. |
University of Vienna |
| 30351001 |
16 |
Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis. |
China Pharmaceutical University |
| 28482218 |
3 |
Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction. |
China Pharmaceutical University |
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