The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
12213077 |
18 |
Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups. |
Duke University |
10091675 |
31 |
Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis. |
Merck Research Laboratories |
28302397 |
73 |
Structure-based discovery of LpxC inhibitors. |
Cubist Pharmaceuticals |
28082037 |
18 |
Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents. |
Kyorin Pharmaceutical |
27326338 |
15 |
LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents. |
Kyorin Pharmaceutical |
24412340 |
24 |
Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors. |
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster |
23914798 |
4 |
Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. |
Duke University |
23499237 |
25 |
Exploring the UDP pocket of LpxC through amino acid analogs. |
Astrazeneca |
22401863 |
30 |
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC. |
Pfizer |
21273067 |
46 |
Design and synthesis of potent Gram-negative specific LpxC inhibitors. |
Merck Research Laboratories |
21194954 |
4 |
Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. |
Jilin University |
18025458 |
10 |
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. |
Duke University Medical Center |