The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
25971770 |
10 |
Progress in discovery of small-molecule modulators of protein-protein interactions via fragment screening. |
Pfizer |
24266771 |
3 |
Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists. |
Ruhr University of Bochum |
23566315 |
3 |
Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators. |
The University of Arizona |
21381769 |
56 |
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. |
Universite£ |
32276831 |
10 |
Chalcones bearing a 3,4,5-trimethoxyphenyl motif are capable of selectively inhibiting oncogenic K-Ras signaling. |
Wright State University |
32250617 |
27 |
Identification of the Clinical Development Candidate |
Array Biopharma |
32023060 |
19 |
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS |
Astrazeneca |
30655937 |
10 |
Inhibitors of G12C Mutant Ras Proteins for the Treatment of Cancers. |
Usona Institute |
31706640 |
5 |
Selective apoptosis-inducing activity of synthetic hydrocarbon-stapled SOS1 helix with d-amino acids in H358 cancer cells expressing KRAS |
China Pharmaceutical University |
31620220 |
11 |
Inhibitors of KRAS May Potentially Provide Effective Cancer Treatment. |
Therachem Research Medilab |
31531201 |
37 |
Discovery of |
Amgen |
31820981 |
62 |
Discovery of a Covalent Inhibitor of KRAS |
TBA |
30613331 |
14 |
Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. |
Array Biopharma |
30455147 |
7 |
Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments. |
University of Houston |
28105276 |
19 |
Covalent Guanosine Mimetic Inhibitors of G12C KRAS. |
Dana Farber Cancer Institute |
26230724 |
10 |
New Frontiers in Druggability. |
Stony Brook University |
23585920 |
11 |
Inhibition of Ras-Effector Interaction by Cyclic Peptides. |
The Ohio State University |
30258528 |
1 |
Precedence and Promise of Covalent Inhibitors of EGFR and KRAS for Patients with Non-Small-Cell Lung Cancer. |
Pfizer |
28740607 |
6 |
Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d. |
Takeda Pharmaceutical |
28457754 |
17 |
Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. |
Takeda Pharmaceutical |