23 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28005385	98	Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidin	Mcgill University
27720549	2	A monocyclic neodysiherbaine analog: Synthesis and evaluation.	Yokohama City University
23121096	86	Ion channels as therapeutic targets: a drug discovery perspective.	Pfizer
18811139	126	1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.	European Research Centre For Drug Discovery and Development (Natsyndrugs)
18269227	14	Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.	University of Copenhagen
17348638	25	Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.	University Walk
10969973	103	4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.	Eli Lilly
22111545	80	Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors.	University of Bristol
20356304	9	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside.	Novartis Pharma
16610801	34	Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.	University Walk
15974569	21	Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.	Eli Lilly
15857151	37	Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.	The Danish University of Pharmaceutical Sciences
15615543	56	Bioisosteric modifications of 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5.	The Danish University of Pharmaceutical Sciences
14667236	61	2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5.	The Danish University of Pharmaceutical Sciences
12747796	39	Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).	The Danish University of Pharmaceutical Sciences
12127516	41	Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5.	Abbott
10821708	138	4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists.	Eli Lilly
24140446	62	GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.	Centro De Investigaci�N Lilly
24119554	52	GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models.	Centro De Investigaci�N Lilly
26833890	18	Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.	Yogi Vemana University
26469307	7	Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.	University of Leipzig
16307879	30	Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.	Gsk