Affinity Data by PubMed id=17348638

PubMed code 17348638

Found 25 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glutamate receptor 2 (Homo sapiens (Human))	BDBM50207594 (2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50207594 (2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (Homo sapiens (Human))	BDBM50207594 (2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUK5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FL...				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor 2 (Homo sapiens (Human))	BDBM50185318 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50207591 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxy-5-phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50207593 ((S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHEN...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor 2 (Homo sapiens (Human))	BDBM50207593 ((S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHEN...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50185318 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor 2 (Homo sapiens (Human))	BDBM50207591 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxy-5-phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50178136 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor 2 (Homo sapiens (Human))	BDBM50178136 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50207591 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxy-5-phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50207598 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50185320 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxyfuran-3...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.88E+3	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50185321 (6-cyano-7-nitroquinoxaline-2,3-dione \| 7-nitro-2,3...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50207593 ((S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHEN...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50185318 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50207599 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50178136 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	402	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50207596 ((S)-1-(2-amino-2-carboxyethyl)-5-bromo-3-(2-carbox...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50207597 ((S)-1-(2-amino-2-carboxyethyl)-5-bromo-3-(2-carbox...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50178145 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	209	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50207592 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxyfuran-3...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50207600 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxy-4,5-di...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50207590 ((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	358	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%