The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28246042 |
2 |
Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors. |
University of Ljubljana |
| 27541007 |
45 |
Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors. |
University of Ljubljana |
| 27100032 |
4 |
New N-phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATPase inhibitors of DNA gyrase. |
University of Ljubljana |
| 27096044 |
30 |
Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design. |
Cubist Pharmaceuticals |
| 26786695 |
12 |
Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB. |
Cubist Pharmaceuticals |
| 26949507 |
4 |
The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic-industrial partnership. |
University College London |
| 26487916 |
8 |
Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors. |
Cubist Pharmaceuticals |
| 26483137 |
2 |
Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria. |
Inter American University of Puerto Rico |
| 26191374 |
4 |
Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV. |
Vertex Pharmaceuticals |
| 26098163 |
66 |
Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site. |
University of Ljubljana |
| 25137573 |
7 |
Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity. |
University of Leeds |
| 24959892 |
152 |
Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
Astrazeneca |
| 24629449 |
2 |
Computer-aided identification of novel 3,5-substituted rhodanine derivatives with activity against Staphylococcus aureus DNA gyrase. |
University of The Sciences |
| 24098982 |
39 |
Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents. |
Astrazeneca R&D Boston |
| 23968485 |
67 |
Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity. |
Actelion Pharmaceuticals |
| 24900376 |
5 |
Combatting Drug-Resistant Bacteria with Gyrase and Topoisomerase IV Inhibitors: Patent Highlight. |
TBA |
| 22814212 |
10 |
Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV. |
Astrazeneca |
| 22041057 |
14 |
Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy. |
Astrazeneca R&D Boston |
| 32027491 |
4 |
Two Decades of Successful SAR-Grounded Stories of the Novel Bacterial Topoisomerase Inhibitors (NBTIs). |
National Institute of Chemistry |
| 32515951 |
2 |
New Broad-Spectrum Antibiotics Containing a Pyrrolobenzodiazepine Ring with Activity against Multidrug-Resistant Gram-Negative Bacteria. |
King'S College London |
| 31276392 |
176 |
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens. |
Angelini |
| 31202995 |
6 |
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies. |
Sapienza University of Rome |
| 30698430 |
32 |
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria. |
Chinese Academy of Sciences |
| 26460684 |
39 |
Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors. |
Cubist Pharmaceuticals |
| 25317480 |
4 |
Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability. |
Vertex Pharmaceuticals |
| 25288496 |
106 |
Structure-guided design and development of novel benzimidazole class of compounds targeting DNA gyraseB enzyme of Staphylococcus aureus. |
Birla Institute of Technology & Science-Pilani |
| 24239017 |
15 |
Design, synthesis and biological evaluation of ?-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors. |
Biota Holdings |
| 23566517 |
69 |
Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV. |
Pfizer |
| 23084277 |
3 |
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities. |
Merck Research Laboratories |
| 21425851 |
14 |
Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA). |
Achillion Pharmaceuticals |
| 20404126 |
20 |
Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones. |
University of Minnesota Medical School |
| 19736016 |
12 |
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. |
Daiichi Sankyo |
| 19147367 |
9 |
Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives. |
Anhui University of Technology |
| 17502409 |
10 |
Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
Achillion Pharmaceuticals |
| 18262793 |
9 |
Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives. |
Anhui University of Technology |
| 18457383 |
6 |
Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl group as a C-10 substituent. |
Kyorin Pharmaceutical |
| 17228862 |
7 |
Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions. |
Achillion Pharmaceuticals |
| 29871847 |
26 |
Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety. |
The Ohio State University |
| 30031974 |
3 |
Design and synthesis of novel 1H-tetrazol-5-amine based potent antimicrobial agents: DNA topoisomerase IV and gyrase affinity evaluation supported by molecular docking studies. |
Medical University of Warsaw |
| 29778894 |
30 |
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity. |
University of Ljubljana |
| 29751233 |
2 |
New developments in non-quinolone-based antibiotics for the inhibiton of bacterial gyrase and topoisomerase IV. |
Islamia College University |
| 29803359 |
13 |
Drug efficacy of novel 3-O-methoxy-4-halo disubstituted 5,7-dimethoxy chromans; evaluated via DNA gyrase inhibition, bacterial cell wall lesion and antibacterial prospective. |
Bharathiar University |
| 28406299 |
46 |
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents. |
Actelion Pharmaceuticals |
| 27689732 |
30 |
Linker-switch approach towards new ATP binding site inhibitors of DNA gyrase B. |
University of Ljubljana |
| 18690678 |
66 |
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships. |
Vertex Pharmaceuticals |
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