41 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28246042	2	Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors.	University of Ljubljana
27100032	4	New N-phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATPase inhibitors of DNA gyrase.	University of Ljubljana
26786695	12	Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.	Cubist Pharmaceuticals
26949507	4	The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic-industrial partnership.	University College London
26483137	2	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.	Inter American University of Puerto Rico
26191374	4	Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.	Vertex Pharmaceuticals
26098163	66	Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site.	University of Ljubljana
23968485	67	Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.	Actelion Pharmaceuticals
32027491	4	Two Decades of Successful SAR-Grounded Stories of the Novel Bacterial Topoisomerase Inhibitors (NBTIs).	National Institute of Chemistry
32515951	2	New Broad-Spectrum Antibiotics Containing a Pyrrolobenzodiazepine Ring with Activity against Multidrug-Resistant Gram-Negative Bacteria.	King'S College London
31276392	176	Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.	Angelini
31202995	6	Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies.	Sapienza University of Rome
30698430	32	Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria.	Chinese Academy of Sciences
25317480	4	Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.	Vertex Pharmaceuticals
25288496	106	Structure-guided design and development of novel benzimidazole class of compounds targeting DNA gyraseB enzyme of Staphylococcus aureus.	Birla Institute of Technology & Science-Pilani
24239017	15	Design, synthesis and biological evaluation of ?-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.	Biota Holdings
23566517	69	Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.	Pfizer
23084277	3	Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities.	Merck Research Laboratories
21425851	14	Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).	Achillion Pharmaceuticals
20404126	20	Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones.	University of Minnesota Medical School
19736016	12	Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria.	Daiichi Sankyo
19147367	9	Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives.	Anhui University of Technology
17502409	10	Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.	Achillion Pharmaceuticals
18262793	9	Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives.	Anhui University of Technology
18457383	6	Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl group as a C-10 substituent.	Kyorin Pharmaceutical
17228862	7	Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.	Achillion Pharmaceuticals
29871847	26	Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety.	The Ohio State University
30031974	3	Design and synthesis of novel 1H-tetrazol-5-amine based potent antimicrobial agents: DNA topoisomerase IV and gyrase affinity evaluation supported by molecular docking studies.	Medical University of Warsaw
29751233	2	New developments in non-quinolone-based antibiotics for the inhibiton of bacterial gyrase and topoisomerase IV.	Islamia College University
29803359	13	Drug efficacy of novel 3-O-methoxy-4-halo disubstituted 5,7-dimethoxy chromans; evaluated via DNA gyrase inhibition, bacterial cell wall lesion and antibacterial prospective.	Bharathiar University
28406299	46	Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.	Actelion Pharmaceuticals
18690678	66	Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.	Vertex Pharmaceuticals