The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28337332 |
41 |
BMS-933043, a Selectivea7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia. |
Bristol-Myers Squibb |
| 28105289 |
51 |
Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] asa7 Nicotinic Receptor Agonists. |
Bristol-Myers Squibb Research and Development |
| 27212066 |
5 |
Conformational analysis of 2-substituted piperazines. |
Retrophin |
| 26994846 |
50 |
Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists. |
Peking University |
| 26840365 |
3 |
New quinoline derivatives as nicotinic receptor modulators. |
University of Florence |
| 26706350 |
48 |
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for thea3ß4 nicotinic acetylcholine receptor subtype. |
Universit£ |
| 24901260 |
12 |
Recent developments in novel antidepressants targetinga4ß2-nicotinic acetylcholine receptors. |
University of Illinois At Chicago |
| 25393758 |
2 |
Dicarba analogues ofa-conotoxin RgIA. Structure, stability, and activity at potential pain targets. |
Monash University (Parkville Campus) |
| 25232969 |
23 |
Chalcones as positive allosteric modulators ofa7 nicotinic acetylcholine receptors: a new target for a privileged structure. |
Instituto De Qu£Mica M£Dica (Iqm-Csic) |
| 25192059 |
36 |
Semisynthetic analogues of toxiferine I and their pharmacological properties ata7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors. |
The German University In Cairo |
| 24814197 |
63 |
Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines asa7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders. |
Critical Therapeutics |
| 24187998 |
96 |
Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists. |
University of Copenhagen |
| 24050653 |
59 |
Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors. |
The Johns Hopkins University School of Medicine |
| 24200193 |
32 |
Characterization of a novela-conotoxin TxID from Conus textile that potently blocks rata3ß4 nicotinic acetylcholine receptors. |
Hainan University |
| 24156938 |
12 |
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents. |
University of Bonn |
| 24090443 |
1 |
Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicotinic acetylcholine receptors. |
Northeastern University |
| 24128660 |
6 |
Design, synthesis and binding affinity of acetylcholine carbamoyl analogues. |
Universit£ |
| 24098954 |
14 |
Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of a7 nicotinic acetylcholine receptors. |
University of California Irvine |
| 23692872 |
98 |
Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor. |
Targacept |
| 23746476 |
1 |
Synthesis and evaluation of a conditionally-silent agonist for thea7 nicotinic acetylcholine receptor. |
University of Florida |
| 23713606 |
116 |
8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35. |
University of Bonn |
| 23561269 |
53 |
Neonicotinic analogues: selective antagonists fora4ß2 nicotinic acetylcholine receptors. |
University of Chile |
| 23507153 |
4 |
Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging ofa7 nicotinic acetylcholine receptors. |
Helmholtz-Zentrum Dresden-Rossendorf |
| 23461628 |
9 |
(+)-Laburnamine, a natural selective ligand and partial agonist for the?4?2 nicotinic receptor subtype. |
Universit£ |
| 24900666 |
6 |
Positive allosteric modulators of nicotinic acetylcholine receptor. |
Dart Neuroscience |
| 22468936 |
49 |
Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789). |
Siena Biotech |
| 22243960 |
88 |
Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein. |
Vu University Amsterdam |
| 21905680 |
26 |
Deconstruction of thea4ß2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine. |
Virginia Commonwealth University |
| 20828128 |
66 |
Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptora7 ligands. |
Vu University Amsterdam |
| 20591663 |
23 |
Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods. |
Glaxosmithkline |
| 23126648 |
213 |
Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. |
Targacept |
| 23092294 |
75 |
Discovery of highly potent and selectivea4ß2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. |
University of Illinois At Chicago |
| 23083093 |
25 |
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward ana7 nicotinic acetylcholine receptor agonist preclinical candidate. |
Siena Biotech |
| 23025891 |
169 |
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands. |
Targacept |
| 22793665 |
190 |
Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selectivea4ß2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. |
Targacept |
| 21919481 |
114 |
Discovery and development ofa7 nicotinic acetylcholine receptor modulators. |
Targacept |
| 22591063 |
12 |
Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711). |
University of Berne |
| 22749278 |
16 |
Diazaspirocyclic compounds as selective ligands for thea4ß2 nicotinic acetylcholine receptor. |
Targacept |
| 22503453 |
59 |
The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement. |
Glaxosmithkline |
| 22503248 |
61 |
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition. |
Glaxosmithkline |
| 20663668 |
43 |
A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists. |
Pfizer |
| 19954975 |
27 |
Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor. |
Abbott Laboratories |
| 19552432 |
90 |
Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity. |
Abbott Laboratories |
| 18989912 |
95 |
Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist. |
University of Copenhagen |
| 18826295 |
7 |
Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding. |
University of Kentucky |
| 18490160 |
13 |
Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity. |
Pfizer |
| 18198823 |
5 |
Allosteric modulators of the alpha7 nicotinic acetylcholine receptor. |
Abbott Laboratories |
| 17470817 |
12 |
Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. |
University of California |
| 17722904 |
146 |
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor. |
University of Copenhagen |
| 17276680 |
3 |
Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors. |
University of Florida |
| 16279810 |
5 |
Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues. |
Research Triangle Institute |
| 16220969 |
219 |
Designed multiple ligands. An emerging drug discovery paradigm. |
Organon Laboratories |
| 16171993 |
45 |
3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation. |
Pfizer |
| 16165358 |
26 |
High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor. |
Eli Lilly |
| 16033252 |
84 |
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. |
The Danish University of Pharmaceutical Sciences |
| 15908213 |
35 |
In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine. |
Pfizer |
| 11741488 |
19 |
2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization. |
University of Minnesota |
| 9484491 |
23 |
Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
Abbott Laboratories |
| 9435889 |
70 |
Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
Abbott Laboratories |
| 15203153 |
23 |
Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the alpha3beta4* nicotinic acetylcholine receptors through modifications to the ester. |
Ohio University |
| 11212100 |
27 |
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist. |
Astrazeneca |
| 22281189 |
63 |
SAR ofa7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore. |
Abbott Laboratories |
| 22222032 |
3 |
Synthesis and binding affinity ata4ß2 anda7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system. |
Universit£ |
| 22014558 |
21 |
New spirocyclic¿²-isoxazoline derivatives related to selective agonists ofa7 neuronal nicotinic acetylcholine receptors. |
Universit£ |
| 21920761 |
52 |
Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors. |
Vu University Amsterdam |
| 21824774 |
17 |
Synthesis and biological activity of a novel class nicotinic acetylcholine receptors (nAChRs) ligands structurally related to anatoxin-a. |
University of Ferrara |
| 21397497 |
18 |
Discovery of non-peptide, small molecule antagonists ofa9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain. |
University of Kentucky |
| 24900227 |
8 |
Exploring a7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB. |
TBA |
| 21216141 |
2 |
Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ). |
Peking University |
| 20472430 |
114 |
Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands. |
Abbott Laboratories |
| 20043678 |
92 |
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models. |
Pfizer |
| 19419141 |
23 |
Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. |
Abbott Laboratories |
| 19331415 |
23 |
Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis. |
Institute |
| 19208472 |
52 |
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists. |
Novartis Institutes For Biomedical Research |
| 19027295 |
108 |
Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC). |
Copenhagen University |
| 18789861 |
26 |
Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators. |
Amgen |
| 17827002 |
6 |
Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors. |
University of Toyama |
| 17604168 |
3 |
Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator. |
Virginia Commonwealth University |
| 17391965 |
28 |
Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. |
University of Chile |
| 15686879 |
9 |
6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model. |
University of California |
| 15050620 |
6 |
Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation. |
University of Maryland |
| 12565964 |
4 |
5-Azidoepibatidine: an exceptionally potent photoaffinity ligand for neuronal alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors. |
University of California |
| 32597184 |
8 |
Development of Conformationally Constrained ?-RgIA Analogues as Stable Peptide Antagonists of Human ?9?10 Nicotinic Acetylcholine Receptors. |
University of Utah |
| 27774124 |
76 |
Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds. |
Mahidol University |
| 31675224 |
62 |
Synthesis, Pharmacological Characterization, and Structure-Activity Relationships of Noncanonical Selective Agonists for ?7 nAChRs. |
University of California-San Diego |
| 30681854 |
50 |
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of ?7 and ?3* Nicotinic Receptors. |
University of Florence |
| 30096653 |
10 |
Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus. |
Univerisity of Eastern Finland (Uef) |
| 31434041 |
12 |
Discovery of fused heterocyclic carboxamide derivatives as novel ?7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. |
Peking University |
| 10447950 |
15 |
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions. |
Targacept |
| 10377231 |
2 |
Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors. |
Cea |
| 31153804 |
13 |
Chemical conversion of nicotinamide into type I positive allosteric modulator of ?7 nAChRs. |
Peking University |
| 30317024 |
34 |
Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing ?7 nAChR activities. |
Fudan University |
| 31986036 |
89 |
Structure and Activity Studies of Disulfide-Deficient Analogues of ?O-Conotoxin GeXIVA. |
Hainan University |
| 32101438 |
20 |
Dimerization of ?-Conotoxins as a Strategy to Enhance the Inhibition of the Human ?7 and ?9?10 Nicotinic Acetylcholine Receptors. |
Ocean University of China |
| 31755711 |
2 |
Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of ?7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization. |
Lupin |
| 31401465 |
52 |
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. |
Julius Maximilian University of W£Rzburg |
| 31276409 |
8 |
Alkaloids Purified from |
American University of Health Sciences |
| 30692022 |
8 |
Di- and heptavalent nicotinic analogues to interfere with ?7 nicotinic acetylcholine receptors. |
Universit£ |
| 9022806 |
7 |
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. |
Abbott Laboratories |
| 30342362 |
6 |
Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the ?7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation. |
University of Milan |
| 29587480 |
16 |
Design and Synthesis of Novel Positive Allosteric Modulators of ?7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice. |
Peking University |
| 11312774 |
36 |
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors. |
University of California |
| 22959526 |
14 |
Identification of novel ?7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric ?7 receptor ligand binding domain. |
Bezmialem Vakif University |
| 30403486 |
35 |
Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an ?7-nAChR, ?9-nAChR Antagonist and of a Pro-Oxidant Mitocan. |
Universit£ |
| 29671588 |
35 |
Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine. |
Indiana State University |
| 29634269 |
11 |
Drimane Sesquiterpenoids Noncompetitively Inhibit Human ?4?2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human ?3?4 and ?7 Subtypes. |
California Northstate University College of Medicine |
| 29541351 |
10 |
Allosteric Modulators of Nicotinic Acetylcholine Receptors Useful for the Treatment of Cognitive Impairment. |
Temple University |
| 28606760 |
57 |
Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors. |
Amgen |
| 29050783 |
40 |
Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the ?7 neuronal nicotinic receptor. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 29384668 |
249 |
Dual Nicotinic Acetylcholine Receptor ?4?2 Antagonists/?7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts. |
University of Copenhagen |
| 27993517 |
43 |
Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists. |
Bristol-Myers Squibb Research and Development |
| 28404523 |
2 |
Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids. |
Nc State University |
| 28885019 |
6 |
Sulfonium as a Surrogate for Ammonium: A New?7 Nicotinic Acetylcholine Receptor Partial Agonist with Desensitizing Activity. |
University of Florida |
| 23406473 |
4 |
New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition. |
Universidad De La Republica |
| 27552286 |
22 |
FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein. |
Avanti Polar Lipids |
| 9802390 |
14 |
Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor. |
Uppsala University |
| 19351152 |
34 |
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. |
University of Leeds |
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