The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 26187704 |
63 |
Discovery of 11ß-hydroxysteroid dehydrogenase type 1 inhibitor. |
Incheon National University |
| 25590374 |
23 |
Hupehenols A-E, selective 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors from Viburnum hupehense. |
Chinese Academy of Sciences |
| 25800116 |
62 |
Synthesis and optimization of picolinamide derivatives as a novel class of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors. |
Seoul National University |
| 25529735 |
27 |
Synthesis and biological evaluation of picolinamides as potent inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). |
Seoul National University |
| 25050169 |
52 |
Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1). |
Bristol-Myers Squibb |
| 25098388 |
7 |
Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus. |
Chinese Academy of Sciences |
| 25453795 |
6 |
Lithocarpic acids O-S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus. |
TBA |
| 24840014 |
25 |
Ingol-type diterpenes from Euphorbia antiquorum with mouse 11ß-hydroxysteroid dehydrogenase type 1 inhibition activity. |
Lanzhou University |
| 24294985 |
42 |
Medicinal chemistry of inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). |
Astrazeneca |
| 24422550 |
107 |
Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice. |
Astrazeneca |
| 24507919 |
45 |
3-Amino-N-adamantyl-3-methylbutanamide derivatives as 11ß-hydroxysteroid dehydrogenase 1 inhibitor. |
Yonsei University |
| 24360604 |
60 |
Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). |
Bristol-Myers Squibb |
| 23845218 |
86 |
1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes. |
Sanofi Deutschland |
| 23795939 |
5 |
11ß-HSD1 inhibitors from Walsura cochinchinensis. |
Chinese Academy of Sciences |
| 23747808 |
51 |
Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11ß-HSD1 inhibitors: potential impact in diabetes. |
Chinese Academy of Sciences |
| 23478147 |
42 |
Discovery of SAR184841, a potent and long-lasting inhibitor of 11ß-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D. |
Sanofi R & D |
| 23414800 |
47 |
Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1. |
Toray Industries |
| 24900572 |
54 |
Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes. |
Pfizer |
| 23153367 |
92 |
Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors. |
Astrazeneca |
| 23088558 |
36 |
Novel acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329). |
Astrazeneca |
| 23013933 |
59 |
Optimisation of pharmacokinetic properties in a neutral series of 11ß-HSD1 inhibitors. |
Astrazeneca |
| 24900382 |
41 |
Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitors. |
TBA |
| 22691057 |
32 |
Discovery of a potent, selective, and orally bioavailable acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017). |
Astrazeneca |
| 22901389 |
28 |
Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11ß-hydroxysteroid dehydrogenase type I. |
Merck Serono |
| 22360639 |
12 |
Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11ß-hydroxysteroid dehydrogenases. |
Chinese Academy of Sciences |
| 24900439 |
34 |
Synthesis and biological evaluation of cyclic sulfamide derivatives as 11ß-hydroxysteroid dehydrogenase 1 inhibitors. |
TBA |
| 22440625 |
44 |
Synthesis and evaluation of piperidine urea derivatives as efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice. |
Chinese Academy of Sciences |
| 24900270 |
22 |
Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes. |
TBA |
| 19564108 |
48 |
4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice. |
Chinese Academy of Sciences |
| 19574056 |
25 |
Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes. |
Chinese Academy of Sciences |
| 18440812 |
113 |
Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. |
Merck Research Laboratories |
| 18434143 |
96 |
Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. |
Merck |
| 18242087 |
18 |
Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling. |
Shanghai Institute of Materia Medica |
| 12190302 |
9 |
Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. |
Biovitrum |
| 22148241 |
3 |
Cyclopeptide Alkaloids from Ziziphus apetala. |
Kunming Institute of Botany |
| 21983444 |
78 |
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1). |
Bristol-Myers Squibb Research & Development |
| 21983439 |
65 |
Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1). |
Bristol-Myers Squibb |
| 21786805 |
130 |
Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11ß-hydroxysteroid dehydrogenase type 1. |
Vitae Pharmaceuticals |
| 21689935 |
55 |
Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1). |
Bristol-Myers Squibb |
| 21334894 |
218 |
Substituted phenyl triazoles as selective inhibitors of 11 β-Hydroxysteroid Dehydrogenase Type 1. |
Merck |
| 21439819 |
49 |
Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1. |
Sanofi-Aventis R&D |
| 21421311 |
135 |
Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome. |
Merck Research Laboratories |
| 21093259 |
38 |
Synthesis and 11ß hydroxysteroid dehydrogenase 1 inhibition of thiazolidine derivatives with an adamantyl group. |
Korea University |
| 20363126 |
50 |
The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors. |
Pfizer |
| 20149650 |
65 |
Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors. |
Merck Research Laboratories |
| 20045318 |
18 |
Discovery of cyclicsulfonamide derivatives as 11beta-hydroxysteroid dehydrogenase 1 inhibitors. |
Korea University |
| 19625185 |
44 |
The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors. |
Schering-Plough Research Institute |
| 19673466 |
101 |
Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model. |
Wyeth Research |
| 19395260 |
29 |
Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I. |
Merck Serono |
| 19053753 |
67 |
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model. |
Amgen |
| 18653260 |
24 |
Structure-based virtual screening for identification of novel 11beta-HSD1 inhibitors. |
Institute of Materia Medica |
| 18578516 |
83 |
Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model. |
Wyeth Research |
| 18440811 |
207 |
4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. |
Merck Research Laboratories |
| 17350260 |
56 |
Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. |
University of Edinburgh |
| 17201418 |
105 |
Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors. |
Abbott Laboratories |
| 17070044 |
102 |
Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors. |
Abbott Laboratories |
| 16996734 |
93 |
Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction. |
Abbott Laboratories |
| 16931002 |
73 |
Discovery of orally active butyrolactam 11beta-HSD1 inhibitors. |
Abbott Laboratories |
| 16899366 |
85 |
Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors. |
Abbott Laboratories |
| 16890427 |
81 |
Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements. |
Abbott Laboratories |
| 16759088 |
38 |
The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening. |
University of Innsbruck |
| 16185866 |
53 |
Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome. |
Merck |
| 31759849 |
24 |
Optimization of cyclic sulfamide derivatives as 11?-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury. |
Korea Research Institute of Chemical Technology |
| 26936592 |
8 |
Limonoids and Triterpenoids as 11?-HSD1 Inhibitors from Walsura robusta. |
Chinese Academy of Sciences |
| 30613321 |
31 |
Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11?-Hydroxysteroid Dehydrogenase Type 1 (11?-HSD-1). |
Bristol-Myers Squibb |
| 28818766 |
23 |
Design, synthesis and in vivo study of novel pyrrolidine-based 11?-HSD1 inhibitors for age-related cognitive dysfunction. |
Universitat De Barcelona |
| 28458137 |
25 |
Synthesis of selective 11?-HSD1 inhibitors based on dammarane scaffold. |
Chinese Academy of Sciences |
| 28537398 |
114 |
Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11?-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. |
Bristol-Myers Squibb |
| 10634944 |
215 |
The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. |
Merck Frosst Centre For Therapeutic Research |
| 21337480 |
17 |
Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans. |
The University of Edinburgh |
| 20187655 |
12 |
Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors. |
Academia Sinica |
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