The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 26317331 |
41 |
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptora and the Proton-Coupled Folate Transporter in Human Tumors. |
Duquesne University |
| 25602637 |
27 |
Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents. |
Duquesne University |
| 25234128 |
59 |
Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptorsa andß and the proton-coupled folate transporter. |
Duquesne University |
| 24111942 |
3 |
Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor a and inhibition of de novo purine nucleotide biosynthesis. |
Duquesne University |
| 22243528 |
12 |
Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier. |
Duquesne University |
| 20085328 |
18 |
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry. |
Duquesne University |
| 18680275 |
14 |
Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. |
Wayne State University School of Medicine |
| 18053726 |
364 |
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. |
Johnson & Johnson Pharmaceutical Research & Development |
| 16686541 |
10 |
Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. |
The Scripps Research Institute |
| 8035423 |
12 |
Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin. |
Harvard Medical School |
| 3121855 |
21 |
Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative. |
Sri International |
| 20527892 |
7 |
Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs. |
Institute of Theoretical Studies Ggmbh |
| | 6 |
Synthesis and biological activity of 2-desamino and 4-deoxy analogs of 5,10-dideazatetrahydrofolic acid (DDATHF) |
TBA |
| 19371039 |
14 |
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry. |
Wayne State University School of Medicine |
| 32503687 |
22 |
Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. |
Duquesne University |
| 27458733 |
48 |
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. |
Duquesne University |
| 10888335 |
5 |
Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase. |
The Scripps Research Institute |
| 9258357 |
25 |
Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition. |
Agouron Pharmaceuticals |
| 29701475 |
109 |
Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. |
Duquesne University |
| 27017552 |
1 |
Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents. |
Hebei Medical University |
| 8164259 |
44 |
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. |
Duquesne University |
| 8027993 |
4 |
Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid. |
Wellcome Research Laboratories |
| 3761327 |
3 |
Synthesis of 10-acetyl-5,8-dideazafolic acid: a potent inhibitor of glycinamide ribonucleotide transformylase. |
TBA |
| 29425443 |
70 |
Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. |
Duquesne University |
| 2542557 |
14 |
Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds. |
University of South Alabama |
| 2498518 |
10 |
Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase. |
University of South Alabama |
| 28830032 |
9 |
Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase. |
Hebei Medical University |
| 2299624 |
12 |
Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
Wellcome Research Laboratories |
| 1995884 |
4 |
Synthesis and biological activity of 5,11-methylenetetrahydro-5- deazahomofolic acid. |
Duquesne University |
| 1573633 |
15 |
Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents. |
Wellcome Research Laboratories |
| 19968566 |
40 |
3D-QSAR, molecular docking studies, and binding mode prediction of thiolactomycin analogs as mtFabH inhibitors. |
China Pharmaceutical University |
| 1315531 |
17 |
Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity. |
Veterans Affairs Medical Center |
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