The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 2795605 |
59 |
Potential antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogues. |
American Cyanamid |
| 25897973 |
29 |
Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors. |
Takeda Pharmaceutical |
| 25349648 |
29 |
Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety. |
Merck Research Laboratories |
| 24900877 |
107 |
Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. |
Merck Research Laboratories |
| 24618302 |
49 |
Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors. |
Merck Research Laboratories |
| 24670009 |
65 |
Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents. |
Amgen |
| 23871442 |
88 |
Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. |
Pfizer |
| 23711919 |
62 |
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3. |
Kitasato University |
| 23665143 |
8 |
Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo. |
Kumamoto University |
| 23535327 |
44 |
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2. |
Kitasato University |
| 23419736 |
58 |
Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors. |
Dongguk University-Seoul |
| 23369538 |
88 |
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1. |
Kitasato University |
| 23317570 |
42 |
Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors. |
Merck Research Laboratories |
| 23116186 |
68 |
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). |
Astrazeneca |
| 23025824 |
6 |
Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloidß (Aß) oligomers-induced neuronal cell death by tricyclic pyrone molecules. |
Kansas State University |
| 18284184 |
4 |
Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors. |
Universita Di Milano |
| 15261286 |
18 |
Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas. |
Korea Research Institute of Bioscience and Biotechnology |
| 7241506 |
40 |
New analgesic drugs derived from phencyclidine. |
TBA |
| 22079027 |
8 |
Conformationally restricted analog and biotin-labeled probe based on beauveriolide III. |
Tohoku University |
| 21413799 |
63 |
Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. |
Hoffmann-La Roche |
| 20833038 |
98 |
Discovery of pyrrolopyridazines as novel DGAT1 inhibitors. |
Amgen |
| | 12 |
RP 73163: A bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor |
TBA |
| | 9 |
Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor |
TBA |
| | 29 |
RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT) |
TBA |
| 19167888 |
20 |
Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression. |
Dainippon Sumitomo Pharma |
| 18620381 |
9 |
Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid. |
Kyoto Pharmaceutical Industries |
| 17157006 |
21 |
Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon. |
National Research Laboratory of Lipid Metabolism and Atherosclerosis |
| 16919944 |
25 |
Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata. |
National Research Laboratory of Lipid Metabolism and Atherosclerosis |
| 16302810 |
9 |
Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors. |
Università |
| 15603959 |
12 |
Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors. |
Korea Research Institute of Bioscience and Biotechnology |
| 15324887 |
2 |
Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. |
National Research Laboratory of Lipid Metabolism and Atherosclerosis |
| 15149654 |
7 |
Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis. |
Korea Research Institute of Bioscience and Biotechnology |
| 11708931 |
44 |
5,6-Diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors. |
Università |
| 32035699 |
8 |
Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome. |
Kitasato University |
| 10890154 |
14 |
Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor. |
Kitasato University |
| 10450977 |
27 |
Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). |
Azwell |
| 30952592 |
206 |
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC). |
Merck |
| 30926247 |
18 |
Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety. |
Merck |
| 8691472 |
49 |
Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. |
RhôNe-Poulenc Rorer |
| 30433781 |
23 |
Discovery of Clinical Candidate 2-(4-(2-((1 H-Benzo[ d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor. |
Kowa |
| 29945757 |
70 |
Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors. |
Kowa |
| 3100794 |
6 |
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity. |
TBA |
| 29456796 |
51 |
Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1. |
Glaxosmithkline |
| 28242547 |
2 |
Vicinal diaryl azole-based urea derivatives as potential cholesterol lowering agents acting through inhibition of SOAT enzymes. |
The Maharaja Sayajirao University of Baroda |
| 19152636 |
26 |
Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors. |
University of Connecticut |
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