The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28523094 |
4 |
Modulation of the Inhibitors of Apoptosis Proteins (IAPs) Activities for Cancer Treatment. |
Therachem Research Medilab (India) |
26191364 |
10 |
Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer. |
Bristol-Myers Squibb Research |
26218264 |
24 |
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP. |
Astex Pharmaceuticals |
26181851 |
26 |
Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. |
Novartis Institutes For Biomedical Research |
25278234 |
25 |
Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists. |
Bristol-Myers Squibb Research & Development |
24631189 |
86 |
Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors. |
Astrazeneca |
24169315 |
9 |
Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells. |
Takeda Pharmaceutical |
24093940 |
85 |
Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain. |
Hoffmann-La Roche |
24083782 |
48 |
Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain. |
Hoffmann-La Roche |
23928071 |
3 |
Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists. |
Takeda Pharmaceutical |
23886811 |
4 |
Solid phase synthesis of Smac/DIABLO-derived peptides using a 'Safety-Catch' resin: identification of potent XIAP BIR3 antagonists. |
Queen'S University of Belfast |
23743278 |
58 |
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. |
Sanford-Burnham Medical Research Institute |
23651223 |
61 |
A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice. |
University of Michigan |
23298277 |
26 |
Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic. |
Takeda Pharmaceutical |
23062821 |
51 |
Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization. |
Fondazione Irccs Istituto Nazionale Dei Tumori |
22148838 |
125 |
Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents. |
University of Michigan |
21443232 |
24 |
A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. |
University of Michigan |
22413863 |
21 |
Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). |
Genentech |
21241056 |
6 |
Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder. |
University of Pittsburgh |
15115387 |
13 |
Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. |
University of Michigan Comprehensive Cancer Center |
22342627 |
36 |
Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents. |
Cisi |
22264476 |
60 |
Discovery of aminopiperidine-based Smac mimetics as IAP antagonists. |
Astrazeneca R&D Boston |
21664815 |
4 |
DNA-instructed acyl transfer reactions for the synthesis of bioactive peptides. |
Humboldt Universit£T Zu Berlin |
21680182 |
64 |
Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP. |
Sanford-Burnham Medical Research Institute |
21462933 |
155 |
Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. |
University of Michigan |
21087868 |
3 |
In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3. |
University of Innsbruck |
20684551 |
40 |
Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. |
University of Michigan |
20443226 |
15 |
Cyclopeptide Smac mimetics as antagonists of IAP proteins. |
University of Michigan |
20189383 |
70 |
Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. |
Genentech |
19819692 |
2 |
Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain. |
Institute For Medical Research |
19138149 |
15 |
Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases. |
Chinese Academy of Sciences |
32142281 |
24 |
Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases. |
Genentech |
27578248 |
7 |
Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents. |
Istituto Di Scienze E Tecnologie Molecolari (Istm) |
31550155 |
60 |
Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy. |
TBA |
30676015 |
43 |
Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives. |
Ningxia Medical University |
30769242 |
14 |
Clinical candidates modulating protein-protein interactions: The fragment-based experience. |
Taros Chemicals |
31188592 |
39 |
Why Some Targets Benefit from beyond Rule of Five Drugs. |
Boston University |
24320998 |
41 |
Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). |
Astrazeneca |
31095386 |
109 |
Covalent Inhibitors of Protein-Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues. |
TBA |
30015078 |
104 |
Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile. |
Quaid-I-Azam University |
29940121 |
91 |
Design of Potent pan-IAP and Lys-Covalent XIAP Selective Inhibitors Using a Thermodynamics Driven Approach. |
University of California Riverside |
29039662 |
62 |
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds. |
Csir-National Chemical Laboratory |
30091600 |
48 |
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one |
Astex Pharmaceuticals |
29057048 |
18 |
Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation. |
Takeda Pharmaceutical |
28492317 |
35 |
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). |
Astex Pharmaceuticals |
28406627 |
110 |
Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84. |
University of Bonn |
23402383 |
6 |
Discovery of new HER2/EGFR dual kinase inhibitors based on the anilinoquinazoline scaffold as potential anti-cancer agents. |
Msa University |
24607578 |
11 |
Development of novel pyrazolone derivatives as inhibitors of aldose reductase: an eco-friendly one-pot synthesis, experimental screening and in silico analysis. |
Swami Ramanand Teerth Marathwada University |
10692507 |
41 |
5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. |
National Institute On Drug Abuse |