The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28306255 |
89 |
Development of Potent and Selective Antagonists for the UTP-Activated P2Y |
University of Bonn |
| 24931384 |
66 |
Discovery of 4-aryl-7-hydroxyindoline-based P2Y1 antagonists as novel antiplatelet agents. |
Bristol-Myers Squibb Research |
| 24513044 |
19 |
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent. |
Bristol-Myers Squibb |
| 24712832 |
66 |
4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 24164581 |
82 |
Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist. |
Bristol-Myers Squibb |
| 23602442 |
28 |
Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility. |
Bristol-Myers Squibb |
| 23368907 |
62 |
Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists. |
Bristol-Myers Squibb Research and Development |
| 16250663 |
8 |
Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. |
University of Bonn |
| 22901672 |
15 |
UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety. |
Bar-Ilan University |
| 21207957 |
163 |
Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor. |
University of Bonn |
| 20146483 |
66 |
Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. |
University of Bonn |
| 20095577 |
25 |
5-OMe-UDP is a potent and selective P2Y(6)-receptor agonist. |
Bar-Ilan University |
| 19419204 |
14 |
Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling. |
University of Bonn |
| 18760862 |
8 |
Identification of hydrolytically stable and selective P2Y(1) receptor agonists. |
Bar-Ilan University |
| 18630897 |
36 |
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. |
University of Bonn |
| 18514530 |
100 |
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. |
Niddk |
| 17483457 |
58 |
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. |
Abbott Laboratories |
| 18006312 |
42 |
Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists. |
University of Bonn |
| 18232657 |
67 |
Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor. |
Inspire Pharmaceuticals |
| 17079144 |
19 |
Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP. |
Ucb-Group |
| 17011188 |
45 |
Novel nucleotide triphosphates as potent P2Y2 agonists. |
Ucb-Group |
| 17302398 |
33 |
Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 17125260 |
69 |
Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. |
University of Bonn |
| 16942026 |
27 |
Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 16539385 |
11 |
Diadenosine and diuridine poly(borano)phosphate analogues: synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y2 receptors. |
Bar-Ilan University |
| 12213051 |
207 |
Purine and pyrimidine (P2) receptors as drug targets. |
National Institute of Diabetes |
| 11985476 |
35 |
Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists. |
National Institute of Diabetes |
| 11754592 |
21 |
Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors. |
National Institute of Diabetes |
| 11206448 |
21 |
Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates. |
Inspire Pharmaceuticals |
| 22386981 |
14 |
Synthesis and P2Y2 receptor agonist activities of uridine 5'-phosphonate analogues. |
Ghent University |
| 22107038 |
32 |
Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues. |
Bar-Ilan University |
| 21528910 |
87 |
Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphated-ester modifications as selective agonists of the P2Y(4) receptor. |
Niddk |
| 21417463 |
80 |
Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. |
University of Bonn |
| 20446735 |
59 |
Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 20004096 |
49 |
Identification of a new class of small molecule C5a receptor antagonists. |
Wyeth Research |
| 19502066 |
25 |
Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 19419868 |
7 |
Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives. |
Ghent University |
| 27331270 |
54 |
Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 26161252 |
43 |
4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 17941622 |
5 |
New iantherans from the marine sponge Ianthella quadrangulata: novel agonists of the P2Y(11) receptor. |
University of Bonn |
| 29254895 |
31 |
Current knowledge on the nucleotide agonists for the P2Y2 receptor. |
China Pharmaceutical University |
| 29558126 |
25 |
Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y |
University Park Nottingham |
| 28938069 |
1 |
Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y |
University of Bonn |
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