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PubMed code 17125260

Compile data set for download or QSAR
Found 69 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199173
PNG
(((2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyr...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H13BrN2O12P2/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(23-8)2-22-26(20,21)24-25(17,18)19/h1,4-6,8,13-14H,2H2,(H,20,21)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 151n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199184
PNG
(5-BROMO-URIDINE-5'-MONOPHOSPHATE | 5-bromo-1-beta-...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H12BrN2O9P/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(21-8)2-20-22(17,18)19/h1,4-6,8,13-14H,2H2,(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199189
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H17N2O15P3/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(25-9)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H,20,21)(H,22,23)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199190
PNG
(3-METHYLURIDINE-5'-MONOPHOSHATE | 3-methyl-1-beta-...)
Show SMILES Cn1c(=O)ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c1=O
Show InChI InChI=1S/C10H15N2O9P/c1-11-6(13)2-3-12(10(11)16)9-8(15)7(14)5(21-9)4-20-22(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199180
PNG
(1-(BETA-D-RIBOFURANOSYL)-2-THIO-URACIL-5'-PHOSPHAT...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H13N2O8PS/c12-5-1-2-11(9(21)10-5)8-7(14)6(13)4(19-8)3-18-20(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,10,12,21)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199182
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H19N2O9P/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(23-11)5-22-24(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 87n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199176
PNG
(2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199182
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H19N2O9P/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(23-11)5-22-24(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199179
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H15N2O9P/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(21-9)3-20-22(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199183
PNG
(3-methyl-1-beta-D-ribofuranosylpyrimidine-2,4-dion...)
Show SMILES Cn1c(=O)ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c1=O
Show InChI InChI=1S/C10H17N2O15P3/c1-11-6(13)2-3-12(10(11)16)9-8(15)7(14)5(25-9)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H,20,21)(H,22,23)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 2.92E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199179
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H15N2O9P/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(21-9)3-20-22(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199189
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H17N2O15P3/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(25-9)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H,20,21)(H,22,23)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199187
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]3OP(O)(=O)O[C@@H]23)c(=O)[nH]1
Show InChI InChI=1S/C12H20N2O17P4/c1-2-3-6-4-8(15)14(12(16)13-6)11-10-9(28-34(22,23)29-10)7(27-11)5-26-33(20,21)31-35(24,25)30-32(17,18)19/h4,7,9-11H,2-3,5H2,1H3,(H,13,16)(H,20,21)(H,22,23)(H,24,25)(H2,17,18,19)/t7-,9-,10-,11-/m1/s1
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50194162
PNG
(3-methyl-1-beta-D-ribofuranosylpyrimidine-2,4-dion...)
Show SMILES Cn1c(=O)ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c1=O
Show InChI InChI=1S/C10H16N2O12P2/c1-11-6(13)2-3-12(10(11)16)9-8(15)7(14)5(23-9)4-22-26(20,21)24-25(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H,20,21)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199187
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]3OP(O)(=O)O[C@@H]23)c(=O)[nH]1
Show InChI InChI=1S/C12H20N2O17P4/c1-2-3-6-4-8(15)14(12(16)13-6)11-10-9(28-34(22,23)29-10)7(27-11)5-26-33(20,21)31-35(24,25)30-32(17,18)19/h4,7,9-11H,2-3,5H2,1H3,(H,13,16)(H,20,21)(H,22,23)(H,24,25)(H2,17,18,19)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199193
PNG
(3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-di...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1OP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H22N2O19P4/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)23)16-15(36-39(24,25)26)14(22)12(35-16)9-34-41(30,31)38-42(32,33)37-40(27,28)29/h1-7,12,14-16,22H,8-9H2,(H,30,31)(H,32,33)(H2,24,25,26)(H2,27,28,29)/t12-,14-,15-,16-/m1/s1
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University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199188
PNG
(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1c(O)cc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O16P3/c12-4-1-5(13)11(9(16)10-4)8-7(15)6(14)3(25-8)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h1,3,6-8,13-15H,2H2,(H,20,21)(H,22,23)(H,10,12,16)(H2,17,18,19)/t3-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199174
PNG
(3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H19N2O10P/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(29-16)9-28-30(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199175
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H16N2O12P2/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(23-9)3-22-26(20,21)24-25(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H,20,21)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199174
PNG
(3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H19N2O10P/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(29-16)9-28-30(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199180
PNG
(1-(BETA-D-RIBOFURANOSYL)-2-THIO-URACIL-5'-PHOSPHAT...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H13N2O8PS/c12-5-1-2-11(9(21)10-5)8-7(14)6(13)4(19-8)3-18-20(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,10,12,21)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199178
PNG
(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)
Show SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(O)cc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H13N2O10P/c12-4-1-5(13)11(9(16)10-4)8-7(15)6(14)3(21-8)2-20-22(17,18)19/h1,3,6-8,13-15H,2H2,(H,10,12,16)(H2,17,18,19)/t3-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199188
PNG
(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1c(O)cc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O16P3/c12-4-1-5(13)11(9(16)10-4)8-7(15)6(14)3(25-8)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h1,3,6-8,13-15H,2H2,(H,20,21)(H,22,23)(H,10,12,16)(H2,17,18,19)/t3-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199186
PNG
(5-bromouridine-5'-uridylic acid (1,1-dichloro-1-ph...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H14BrCl2N2O14P3/c11-3-1-15(9(19)14-7(3)18)8-6(17)5(16)4(28-8)2-27-32(25,26)29-31(23,24)10(12,13)30(20,21)22/h1,4-6,8,16-17H,2H2,(H,23,24)(H,25,26)(H,14,18,19)(H2,20,21,22)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 3.99E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199190
PNG
(3-METHYLURIDINE-5'-MONOPHOSHATE | 3-methyl-1-beta-...)
Show SMILES Cn1c(=O)ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c1=O
Show InChI InChI=1S/C10H15N2O9P/c1-11-6(13)2-3-12(10(11)16)9-8(15)7(14)5(21-9)4-20-22(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50194162
PNG
(3-methyl-1-beta-D-ribofuranosylpyrimidine-2,4-dion...)
Show SMILES Cn1c(=O)ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c1=O
Show InChI InChI=1S/C10H16N2O12P2/c1-11-6(13)2-3-12(10(11)16)9-8(15)7(14)5(23-9)4-22-26(20,21)24-25(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H,20,21)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199181
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H20N2O12P2/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(25-11)5-24-28(22,23)26-27(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H,22,23)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199172
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H21N2O15P3/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(27-11)5-26-31(22,23)29-32(24,25)28-30(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H,22,23)(H,24,25)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50118239
PNG
(CHEMBL130266 | UDP | Uridine diphosphate | uridine...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 42n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199178
PNG
(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)
Show SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(O)cc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H13N2O10P/c12-4-1-5(13)11(9(16)10-4)8-7(15)6(14)3(21-8)2-20-22(17,18)19/h1,3,6-8,13-15H,2H2,(H,10,12,16)(H2,17,18,19)/t3-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199192
PNG
(((2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyr...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H14BrN2O15P3/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(25-8)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h1,4-6,8,13-14H,2H2,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 291n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199177
PNG
(3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H21N2O16P3/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(33-16)9-32-37(28,29)35-38(30,31)34-36(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H,28,29)(H,30,31)(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199184
PNG
(5-BROMO-URIDINE-5'-MONOPHOSPHATE | 5-bromo-1-beta-...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H12BrN2O9P/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(21-8)2-20-22(17,18)19/h1,4-6,8,13-14H,2H2,(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199174
PNG
(3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H19N2O10P/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(29-16)9-28-30(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199176
PNG
(2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 1.77E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Rattus norvegicus)		BDBM50199173
PNG
(((2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyr...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H13BrN2O12P2/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(23-8)2-22-26(20,21)24-25(17,18)19/h1,4-6,8,13-14H,2H2,(H,20,21)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 130n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at rat P2Y6 receptor assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199176
PNG
(2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S |r|
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 50n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199187
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]3OP(O)(=O)O[C@@H]23)c(=O)[nH]1
Show InChI InChI=1S/C12H20N2O17P4/c1-2-3-6-4-8(15)14(12(16)13-6)11-10-9(28-34(22,23)29-10)7(27-11)5-26-33(20,21)31-35(24,25)30-32(17,18)19/h4,7,9-11H,2-3,5H2,1H3,(H,13,16)(H,20,21)(H,22,23)(H,24,25)(H2,17,18,19)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199177
PNG
(3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H21N2O16P3/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(33-16)9-32-37(28,29)35-38(30,31)34-36(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H,28,29)(H,30,31)(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199175
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H16N2O12P2/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(23-9)3-22-26(20,21)24-25(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H,20,21)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50194162
PNG
(3-methyl-1-beta-D-ribofuranosylpyrimidine-2,4-dion...)
Show SMILES Cn1c(=O)ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c1=O
Show InChI InChI=1S/C10H16N2O12P2/c1-11-6(13)2-3-12(10(11)16)9-8(15)7(14)5(23-9)4-22-26(20,21)24-25(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H,20,21)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199186
PNG
(5-bromouridine-5'-uridylic acid (1,1-dichloro-1-ph...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H14BrCl2N2O14P3/c11-3-1-15(9(19)14-7(3)18)8-6(17)5(16)4(28-8)2-27-32(25,26)29-31(23,24)10(12,13)30(20,21)22/h1,4-6,8,16-17H,2H2,(H,23,24)(H,25,26)(H,14,18,19)(H2,20,21,22)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 354n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199182
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H19N2O9P/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(23-11)5-22-24(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199191
PNG
(((2R,3S,4R,5R)-5-(2,4-dioxo-3-(2-oxo-2-phenylethyl...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H20N2O13P2/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(31-16)9-30-34(28,29)32-33(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H,28,29)(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199189
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H17N2O15P3/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(25-9)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H,20,21)(H,22,23)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50194160
PNG
((2R,3R,4S,5R)-1-(3,4-dihydroxy-5-(diphosphoryloxym...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H14N2O11P2S/c12-5-1-2-11(9(25)10-5)8-7(14)6(13)4(21-8)3-20-24(18,19)22-23(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,10,12,25)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199186
PNG
(5-bromouridine-5'-uridylic acid (1,1-dichloro-1-ph...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H14BrCl2N2O14P3/c11-3-1-15(9(19)14-7(3)18)8-6(17)5(16)4(28-8)2-27-32(25,26)29-31(23,24)10(12,13)30(20,21)22/h1,4-6,8,16-17H,2H2,(H,23,24)(H,25,26)(H,14,18,19)(H2,20,21,22)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 120n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199183
PNG
(3-methyl-1-beta-D-ribofuranosylpyrimidine-2,4-dion...)
Show SMILES Cn1c(=O)ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c1=O
Show InChI InChI=1S/C10H17N2O15P3/c1-11-6(13)2-3-12(10(11)16)9-8(15)7(14)5(25-9)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H,20,21)(H,22,23)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 564n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199183
PNG
(3-methyl-1-beta-D-ribofuranosylpyrimidine-2,4-dion...)
Show SMILES Cn1c(=O)ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c1=O
Show InChI InChI=1S/C10H17N2O15P3/c1-11-6(13)2-3-12(10(11)16)9-8(15)7(14)5(25-9)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H,20,21)(H,22,23)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199184
PNG
(5-BROMO-URIDINE-5'-MONOPHOSPHATE | 5-bromo-1-beta-...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H12BrN2O9P/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(21-8)2-20-22(17,18)19/h1,4-6,8,13-14H,2H2,(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50194160
PNG
((2R,3R,4S,5R)-1-(3,4-dihydroxy-5-(diphosphoryloxym...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H14N2O11P2S/c12-5-1-2-11(9(25)10-5)8-7(14)6(13)4(21-8)3-20-24(18,19)22-23(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,10,12,25)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199172
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H21N2O15P3/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(27-11)5-26-31(22,23)29-32(24,25)28-30(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H,22,23)(H,24,25)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199193
PNG
(3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-di...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1OP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H22N2O19P4/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)23)16-15(36-39(24,25)26)14(22)12(35-16)9-34-41(30,31)38-42(32,33)37-40(27,28)29/h1-7,12,14-16,22H,8-9H2,(H,30,31)(H,32,33)(H2,24,25,26)(H2,27,28,29)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199173
PNG
(((2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyr...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H13BrN2O12P2/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(23-8)2-22-26(20,21)24-25(17,18)19/h1,4-6,8,13-14H,2H2,(H,20,21)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 7.20E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199181
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H20N2O12P2/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(25-11)5-24-28(22,23)26-27(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H,22,23)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199175
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H16N2O12P2/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(23-9)3-22-26(20,21)24-25(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H,20,21)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199188
PNG
(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1c(O)cc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O16P3/c12-4-1-5(13)11(9(16)10-4)8-7(15)6(14)3(25-8)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h1,3,6-8,13-15H,2H2,(H,20,21)(H,22,23)(H,10,12,16)(H2,17,18,19)/t3-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199192
PNG
(((2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyr...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H14BrN2O15P3/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(25-8)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h1,4-6,8,13-14H,2H2,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 3.46E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199191
PNG
(((2R,3S,4R,5R)-5-(2,4-dioxo-3-(2-oxo-2-phenylethyl...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H20N2O13P2/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(31-16)9-30-34(28,29)32-33(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H,28,29)(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a 70n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199173
PNG
(((2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyr...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H13BrN2O12P2/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(23-8)2-22-26(20,21)24-25(17,18)19/h1,4-6,8,13-14H,2H2,(H,20,21)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 3.67E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199177
PNG
(3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H21N2O16P3/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(33-16)9-32-37(28,29)35-38(30,31)34-36(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H,28,29)(H,30,31)(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199181
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H20N2O12P2/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(25-11)5-24-28(22,23)26-27(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H,22,23)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 6


(Homo sapiens (Human))		BDBM50199178
PNG
(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)
Show SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(O)cc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H13N2O10P/c12-4-1-5(13)11(9(16)10-4)8-7(15)6(14)3(21-8)2-20-22(17,18)19/h1,3,6-8,13-15H,2H2,(H,10,12,16)(H2,17,18,19)/t3-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199172
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H21N2O15P3/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(27-11)5-26-31(22,23)29-32(24,25)28-30(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H,22,23)(H,24,25)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199191
PNG
(((2R,3S,4R,5R)-5-(2,4-dioxo-3-(2-oxo-2-phenylethyl...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H20N2O13P2/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(31-16)9-30-34(28,29)32-33(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H,28,29)(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50199192
PNG
(((2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyr...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H14BrN2O15P3/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(25-8)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h1,4-6,8,13-14H,2H2,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 347n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 4


(Homo sapiens (Human))		BDBM50199179
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H15N2O9P/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(21-9)3-20-22(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
P2Y purinoceptor 2


(Homo sapiens (Human))		BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 43n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA

J Med Chem 49: 7076-87 (2006)


Article DOI: 10.1021/jm060848j
BindingDB Entry DOI: 10.7270/Q2SN09RW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%