The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
26632965 |
80 |
Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents. |
Duke University School of Medicine |
26102506 |
40 |
Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. |
Celgene |
25387153 |
53 |
Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring. |
University Hospital Hradec Kralove |
24893124 |
4 |
Development of synthetic lethality anticancer therapeutics. |
The University of Texas M.D. Anderson Cancer Center |
25589928 |
37 |
Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors. |
Novartis Institutes For Biomedical Research |
25589927 |
36 |
Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR Inhibitors. |
Novartis Institutes For Biomedical Research |
23855836 |
147 |
1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity. |
Newcastle University |
23726034 |
117 |
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. |
Novartis Institutes For Biomedical Research |
23394205 |
106 |
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. |
Astrazeneca |
22726925 |
216 |
Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease. |
Cellzome |
22835870 |
29 |
Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. |
Astrazeneca |
15975507 |
13 |
Features of selective kinase inhibitors. |
University of California San Francisco |
18077363 |
314 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
University of Oxford |
21413798 |
174 |
Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. |
Vertex Pharmaceuticals |
16767085 |
2 |
Small molecule-based reversible reprogramming of cellular lifespan. |
Korea Advanced Institute of Science and Technology |
19733066 |
25 |
Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR. |
Kudos Pharmaceuticals |
17371003 |
128 |
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. |
Newcastle University |
15658870 |
104 |
Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. |
Newcastle University |
15546735 |
25 |
Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. |
University of Newcastle |
29308895 |
24 |
Highly Selective, Potent, and Oral mTOR Inhibitor for Treatment of Cancer as Autophagy Inducer. |
Nankai University |