The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
26619267 |
29 |
3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors. |
Mcgill University |
24763264 |
7 |
Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo. |
University of Helsinki |
23121075 |
119 |
P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy. |
University of Antwerp |
20058865 |
59 |
Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. |
Mcgill University |
18053726 |
364 |
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. |
Johnson & Johnson Pharmaceutical Research & Development |
16033257 |
52 |
Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions. |
University of Kuopio |
10821712 |
18 |
Quantized surface complementarity diversity (QSCD): a model based on small molecule-target complementarity. |
Neogenesis |
| 34 |
Peptidyl -keto thiazole as potent thrombin inhibitors |
TBA |
| 6 |
α-Ketothiazole inhibitors of prolyl endopeptidase |
TBA |
16279765 |
3 |
Synthesis and characterization of the novel fluorescent prolyl oligopeptidase inhibitor 4-fluoresceinthiocarbamoyl-6-aminocaproyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine. |
University of Kuopio |
15509157 |
14 |
A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors. |
University of Kuopio |
14521416 |
29 |
New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides. |
University of Kuopio |
12238937 |
13 |
Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors. |
University of Kuopio |
31857839 |
28 |
Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors. |
University of Helsinki |
7932578 |
20 |
Synthesis and structure-activity relationships of peptidyl alpha-keto heterocycles as novel inhibitors of prolyl endopeptidase. |
Meiji Seika Kaisha |