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PubMed code 14521416

Compile data set for download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prolyl endopeptidase


(Sus scrofa)		BDBM50134170
PNG
(1-((S)-2-Cyclopentanecarbonyl-pyrrolidin-1-yl)-5-{...)
Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)C1CCCC1)CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)CO
Show InChI InChI=1S/C28H43N3O6/c1-28(2,16-24(34)29-13-6-11-21(29)26(36)19-8-3-4-9-19)17-25(35)30-14-7-12-22(30)27(37)31-15-5-10-20(31)23(33)18-32/h19-22,32H,3-18H2,1-2H3/t20-,21-,22-/m0/s1
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n/an/a 0.320n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134160
PNG
(2-Hydroxy-1-[(S)-1-((S)-1-{3-[(S)-2-(pyrrolidine-1...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C28H36N4O6/c33-18-24(34)21-9-4-14-30(21)28(38)23-11-6-16-32(23)26(36)20-8-3-7-19(17-20)25(35)31-15-5-10-22(31)27(37)29-12-1-2-13-29/h3,7-8,17,21-23,33H,1-2,4-6,9-16,18H2/t21-,22-,23-/m0/s1
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n/an/a 0.390n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134150
PNG
((S)-1-{(S)-1-[5-((S)-2-Cyclopentanecarbonyl-pyrrol...)
Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)C1CCCC1)CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C27H40N4O4/c1-27(2,16-23(32)30-14-6-11-21(30)25(34)19-8-3-4-9-19)17-24(33)31-15-7-12-22(31)26(35)29-13-5-10-20(29)18-28/h19-22H,3-17H2,1-2H3/t20-,21-,22-/m0/s1
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n/an/a 0.570n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134168
PNG
(1-((R)-1-{(S)-1-[3-((R)-2-Cyclopentanecarbonyl-pyr...)
Show SMILES OCC(=O)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@@H]1C(=O)C1CCCC1
Show InChI InChI=1S/C29H37N3O6/c33-18-25(34)22-11-4-14-30(22)29(38)24-13-6-16-32(24)28(37)21-10-3-9-20(17-21)27(36)31-15-5-12-23(31)26(35)19-7-1-2-8-19/h3,9-10,17,19,22-24,33H,1-2,4-8,11-16,18H2/t22-,23-,24+/m1/s1
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n/an/a 0.610n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134161
PNG
((R)-1-{(S)-1-[3-((R)-2-Cyclohexanecarbonyl-pyrroli...)
Show SMILES O=C([C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C#N)C1CCCCC1
Show InChI InChI=1S/C29H36N4O4/c30-19-23-12-5-15-31(23)29(37)25-14-7-17-33(25)28(36)22-11-4-10-21(18-22)27(35)32-16-6-13-24(32)26(34)20-8-2-1-3-9-20/h4,10-11,18,20,23-25H,1-3,5-9,12-17H2/t23-,24-,25+/m1/s1
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n/an/a 0.720n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134175
PNG
((R)-1-{(S)-1-[3-((R)-2-Cyclopentanecarbonyl-pyrrol...)
Show SMILES O=C(C1CCCC1)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C#N
Show InChI InChI=1S/C28H34N4O4/c29-18-22-11-4-14-30(22)28(36)24-13-6-16-32(24)27(35)21-10-3-9-20(17-21)26(34)31-15-5-12-23(31)25(33)19-7-1-2-8-19/h3,9-10,17,19,22-24H,1-2,4-8,11-16H2/t22-,23-,24+/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134164
PNG
(1-((R)-1-{(S)-1-[3-((R)-2-Acetyl-pyrrolidine-1-car...)
Show SMILES CC(=O)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C(=O)CO
Show InChI InChI=1S/C25H31N3O6/c1-16(30)19-8-3-11-26(19)23(32)17-6-2-7-18(14-17)24(33)28-13-5-10-21(28)25(34)27-12-4-9-20(27)22(31)15-29/h2,6-7,14,19-21,29H,3-5,8-13,15H2,1H3/t19-,20-,21+/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134159
PNG
((R)-1-{(S)-1-[3-((R)-2-Benzoyl-pyrrolidine-1-carbo...)
Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@@H]1C(=O)c1ccccc1)N1CCC[C@@H]1C#N
Show InChI InChI=1S/C29H30N4O4/c30-19-23-12-5-15-31(23)29(37)25-14-7-17-33(25)28(36)22-11-4-10-21(18-22)27(35)32-16-6-13-24(32)26(34)20-8-2-1-3-9-20/h1-4,8-11,18,23-25H,5-7,12-17H2/t23-,24-,25+/m1/s1
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n/an/a 1.30n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134167
PNG
((S)-1-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-py...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C27H34N4O5/c32-18-21-9-4-14-29(21)27(36)23-11-6-16-31(23)25(34)20-8-3-7-19(17-20)24(33)30-15-5-10-22(30)26(35)28-12-1-2-13-28/h3,7-8,17-18,21-23H,1-2,4-6,9-16H2/t21-,22-,23-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134163
PNG
((S)-1-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-py...)
Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N)N1CCCC1
Show InChI InChI=1S/C27H33N5O4/c28-18-21-9-4-14-30(21)27(36)23-11-6-16-32(23)25(34)20-8-3-7-19(17-20)24(33)31-15-5-10-22(31)26(35)29-12-1-2-13-29/h3,7-8,17,21-23H,1-2,4-6,9-16H2/t21-,22-,23-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134174
PNG
((R)-1-{(S)-1-[3-((R)-2-Isobutyryl-pyrrolidine-1-ca...)
Show SMILES CC(C)C(=O)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C#N
Show InChI InChI=1S/C26H32N4O4/c1-17(2)23(31)21-10-5-13-29(21)24(32)18-7-3-8-19(15-18)25(33)30-14-6-11-22(30)26(34)28-12-4-9-20(28)16-27/h3,7-8,15,17,20-22H,4-6,9-14H2,1-2H3/t20-,21-,22+/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134154
PNG
((R)-1-{(S)-1-[3-((R)-2-Acetyl-pyrrolidine-1-carbon...)
Show SMILES CC(=O)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C#N
Show InChI InChI=1S/C24H28N4O4/c1-16(29)20-9-4-12-27(20)22(30)17-6-2-7-18(14-17)23(31)28-13-5-10-21(28)24(32)26-11-3-8-19(26)15-25/h2,6-7,14,19-21H,3-5,8-13H2,1H3/t19-,20-,21+/m1/s1
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n/an/a 4.20n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134155
PNG
(3,3-Dimethyl-1,5-bis-[(S)-2-(pyrrolidine-1-carbony...)
Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)N1CCCC1)CC(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C25H40N4O4/c1-25(2,17-21(30)28-15-7-9-19(28)23(32)26-11-3-4-12-26)18-22(31)29-16-8-10-20(29)24(33)27-13-5-6-14-27/h19-20H,3-18H2,1-2H3/t19-,20-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134156
PNG
(CHEMBL138550 | Cyclopentyl-((R)-1-{3-[(S)-2-(pyrro...)
Show SMILES O=C(C1CCCC1)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C27H35N3O4/c31-24(19-8-1-2-9-19)22-12-6-16-29(22)25(32)20-10-5-11-21(18-20)26(33)30-17-7-13-23(30)27(34)28-14-3-4-15-28/h5,10-11,18-19,22-23H,1-4,6-9,12-17H2/t22-,23+/m1/s1
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n/an/a 14n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134176
PNG
(CHEMBL138367 | Phenyl-((R)-1-{3-[(S)-2-(pyrrolidin...)
Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@@H]1C(=O)c1ccccc1)N1CCCC1
Show InChI InChI=1S/C28H31N3O4/c32-25(20-9-2-1-3-10-20)23-13-7-17-30(23)26(33)21-11-6-12-22(19-21)27(34)31-18-8-14-24(31)28(35)29-15-4-5-16-29/h1-3,6,9-12,19,23-24H,4-5,7-8,13-18H2/t23-,24+/m1/s1
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n/an/a 18n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134171
PNG
(((R)-1-{3-[(S)-2-(Azepane-1-carbonyl)-pyrrolidine-...)
Show SMILES O=C([C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCCCC1)N1CCCC1
Show InChI InChI=1S/C28H38N4O4/c33-25(31-18-8-12-23(31)27(35)29-14-3-1-2-4-15-29)21-10-7-11-22(20-21)26(34)32-19-9-13-24(32)28(36)30-16-5-6-17-30/h7,10-11,20,23-24H,1-6,8-9,12-19H2/t23-,24+/m0/s1
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n/an/a 23n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134166
PNG
(CHEMBL141158 | {3-[(S)-2-(Pyrrolidine-1-carbonyl)-...)
Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C26H34N4O4/c31-23(29-16-6-10-21(29)25(33)27-12-1-2-13-27)19-8-5-9-20(18-19)24(32)30-17-7-11-22(30)26(34)28-14-3-4-15-28/h5,8-9,18,21-22H,1-4,6-7,10-17H2/t21-,22-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134178
PNG
((S)-1-{3-[(R)-2-(Pyrrolidine-1-carbonyl)-pyrrolidi...)
Show SMILES O=C(NCc1ccccc1)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C29H34N4O4/c34-26(30-20-21-9-2-1-3-10-21)24-13-7-17-32(24)27(35)22-11-6-12-23(19-22)28(36)33-18-8-14-25(33)29(37)31-15-4-5-16-31/h1-3,6,9-12,19,24-25H,4-5,7-8,13-18,20H2,(H,30,34)/t24-,25+/m0/s1
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n/an/a 31n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134151
PNG
(((R)-1-{3-[(S)-2-(Piperazine-1-carbonyl)-pyrrolidi...)
Show SMILES O=C([C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCNCC1)N1CCCC1
Show InChI InChI=1S/C26H35N5O4/c32-23(30-14-4-8-21(30)25(34)28-12-1-2-13-28)19-6-3-7-20(18-19)24(33)31-15-5-9-22(31)26(35)29-16-10-27-11-17-29/h3,6-7,18,21-22,27H,1-2,4-5,8-17H2/t21-,22+/m1/s1
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n/an/a 33n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134153
PNG
(CHEMBL140310 | N-((S)-1-Methyl-2-oxo-2-pyrrolidin-...)
Show SMILES C[C@H](NC(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1)C(=O)N1CCCC1
Show InChI InChI=1S/C24H32N4O4/c1-17(22(30)26-11-2-3-12-26)25-21(29)18-8-6-9-19(16-18)23(31)28-15-7-10-20(28)24(32)27-13-4-5-14-27/h6,8-9,16-17,20H,2-5,7,10-15H2,1H3,(H,25,29)/t17-,20-/m0/s1
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n/an/a 39n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134173
PNG
((R)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidi...)
Show SMILES COC(=O)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C23H29N3O5/c1-31-23(30)19-10-6-14-26(19)21(28)17-8-4-7-16(15-17)20(27)25-13-5-9-18(25)22(29)24-11-2-3-12-24/h4,7-8,15,18-19H,2-3,5-6,9-14H2,1H3/t18-,19+/m0/s1
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n/an/a 54n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134172
PNG
(1-((R)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrol...)
Show SMILES CC(=O)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C23H29N3O4/c1-16(27)19-9-5-13-25(19)21(28)17-7-4-8-18(15-17)22(29)26-14-6-10-20(26)23(30)24-11-2-3-12-24/h4,7-8,15,19-20H,2-3,5-6,9-14H2,1H3/t19-,20+/m1/s1
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n/an/a 65n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134152
PNG
(CHEMBL140059 | [3-((R)-2-Cyclopentanecarbonyl-pyrr...)
Show SMILES O=C(C1CCCC1)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)C1CCCC1
Show InChI InChI=1S/C28H36N2O4/c31-25(19-8-1-2-9-19)23-14-6-16-29(23)27(33)21-12-5-13-22(18-21)28(34)30-17-7-15-24(30)26(32)20-10-3-4-11-20/h5,12-13,18-20,23-24H,1-4,6-11,14-17H2/t23-,24+
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n/an/a 78n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134165
PNG
(CHEMBL344019 | N-((R)-1-Benzyl-2-oxo-2-pyrrolidin-...)
Show SMILES O=C([C@@H](Cc1ccccc1)NC(=O)c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C34H38N4O4/c39-31(35-29(22-25-12-3-1-4-13-25)33(41)37-18-7-8-19-37)27-16-11-17-28(24-27)32(40)36-30(23-26-14-5-2-6-15-26)34(42)38-20-9-10-21-38/h1-6,11-17,24,29-30H,7-10,18-23H2,(H,35,39)(H,36,40)/t29-,30+
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n/an/a 81n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134158
PNG
(CHEMBL142133 | N-((R)-1-Methyl-2-oxo-2-pyrrolidin-...)
Show SMILES C[C@@H](NC(=O)c1cccc(c1)C(=O)N[C@@H](C)C(=O)N1CCCC1)C(=O)N1CCCC1
Show InChI InChI=1S/C22H30N4O4/c1-15(21(29)25-10-3-4-11-25)23-19(27)17-8-7-9-18(14-17)20(28)24-16(2)22(30)26-12-5-6-13-26/h7-9,14-16H,3-6,10-13H2,1-2H3,(H,23,27)(H,24,28)/t15-,16+
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n/an/a 87n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134169
PNG
(CHEMBL141728 | N-[3-Methylsulfanyl-1-((R)-pyrrolid...)
Show SMILES CSCC[C@@H](NC(=O)c1cccc(c1)C(=O)N[C@@H](CCSC)C(=O)N1CCCC1)C(=O)N1CCCC1
Show InChI InChI=1S/C26H38N4O4S2/c1-35-16-10-21(25(33)29-12-3-4-13-29)27-23(31)19-8-7-9-20(18-19)24(32)28-22(11-17-36-2)26(34)30-14-5-6-15-30/h7-9,18,21-22H,3-6,10-17H2,1-2H3,(H,27,31)(H,28,32)/t21-,22+
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n/an/a 110n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134162
PNG
(4-((R)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrol...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C31H43N5O6/c1-31(2,3)42-30(41)34-19-17-33(18-20-34)29(40)25-12-8-16-36(25)27(38)23-10-6-9-22(21-23)26(37)35-15-7-11-24(35)28(39)32-13-4-5-14-32/h6,9-10,21,24-25H,4-5,7-8,11-20H2,1-3H3/t24-,25+/m0/s1
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n/an/a 170n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134177
PNG
((R)-1-[3-((S)-2-Cyclopentanecarbonyl-pyrrolidine-1...)
Show SMILES COC(=O)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)C1CCCC1
Show InChI InChI=1S/C24H30N2O5/c1-31-24(30)20-12-6-14-26(20)23(29)18-10-4-9-17(15-18)22(28)25-13-5-11-19(25)21(27)16-7-2-3-8-16/h4,9-10,15-16,19-20H,2-3,5-8,11-14H2,1H3/t19-,20+/m0/s1
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n/an/a 640n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)		BDBM50134157
PNG
(CHEMBL139617 | N,N'-Bis-(2-oxo-2-pyrrolidin-1-yl-e...)
Show SMILES O=C(CNC(=O)c1cccc(c1)C(=O)NCC(=O)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C20H26N4O4/c25-17(23-8-1-2-9-23)13-21-19(27)15-6-5-7-16(12-15)20(28)22-14-18(26)24-10-3-4-11-24/h5-7,12H,1-4,8-11,13-14H2,(H,21,27)(H,22,28)
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n/an/a 640n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain

J Med Chem 46: 4543-51 (2003)


Article DOI: 10.1021/jm030811o
BindingDB Entry DOI: 10.7270/Q2H70F6R
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%