Found 9 hits for monomerid = 24627 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM24627
(1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 1.85E+5 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex
| Assay Description CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1.... |
J Med Chem 51: 4986-99 (2008)
Article DOI: 10.1021/jm800382h BindingDB Entry DOI: 10.7270/Q24X563W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
DNA repair and recombination protein RadA
(Pyrococcus furiosus) | BDBM24627
(1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a |
University of Cambridge
| Assay Description The thermal-shift denaturation assay was performed on an iCycler iQ Real Time Detection System (BioRad) in 96-well iCycler iQ PCR plates sealed with ... |
Chembiochem 14: 332-42 (2013)
Article DOI: 10.1002/cbic.201200521 BindingDB Entry DOI: 10.7270/Q2QF8RHG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM24627
(1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB PubMed
| n/a | n/a | 1.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assay |
Bioorg Med Chem Lett 25: 3420-35 (2015)
BindingDB Entry DOI: 10.7270/Q2736SQ1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Nitric oxide synthase, brain
(Homo sapiens (Human)) | BDBM24627
(1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 1.78E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
UNED
Curated by ChEMBL
| Assay Description Inhibition of recombinant NOS1 assessed as citrulline formation |
Bioorg Med Chem 17: 6180-7 (2009)
Article DOI: 10.1016/j.bmc.2009.07.067 BindingDB Entry DOI: 10.7270/Q2ZG6SBD |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM24627
(1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | 3.60E+5 | n/a | n/a | n/a | n/a | n/a |
Osaka University
Curated by ChEMBL
| Assay Description Binding affinity to recombinant ferric state of IDO1 (unknown origin) expressed in Escherichia coli assessed as dissociation constant incubated for 3... |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.08.011 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM24627
(1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 1.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline R&D
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
J Med Chem 54: 5131-43 (2011)
Article DOI: 10.1021/jm200349b BindingDB Entry DOI: 10.7270/Q2F47PHP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM24627
(1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | 5.30E+6 | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Binding affinity to human HSP90alpha assessed as 2D1H-15N chemical shift perturbation by NMR spectroscopy |
Bioorg Med Chem Lett 21: 5778-83 (2011)
Checked by Author Article DOI: 10.1016/j.bmcl.2011.08.001 BindingDB Entry DOI: 10.7270/Q2QJ7HQX |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM24627
(1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | 8.10E+4 | n/a | n/a | n/a | n/a | n/a |
Osaka University
Curated by ChEMBL
| Assay Description Binding affinity to recombinant ferrous state of IDO1 (unknown origin) expressed in Escherichia coli assessed as dissociation constant incubated for ... |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.08.011 |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM24627
(1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | >4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline R&D
Curated by ChEMBL
| Assay Description Inhibition of AKT1 expressed in Escherichia coli or baculovirus-infected insect cells by scintillation proximity assay |
J Med Chem 54: 5131-43 (2011)
Article DOI: 10.1021/jm200349b BindingDB Entry DOI: 10.7270/Q2F47PHP |
More data for this Ligand-Target Pair | |