null
SMILES: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](C2CCCC2)N2Cc3ccccc3C2=O)cc1
InChI Key: InChIKey=YMRFUSDFDQZOFK-STXQHDJLSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM454875 (US10730870, Example 38 | US11512083, Example 38) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 2.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ... | US Patent US10730870 (2020) BindingDB Entry DOI: 10.7270/Q2WD43MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM454875 (US10730870, Example 38 | US11512083, Example 38) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 758 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ... | US Patent US10730870 (2020) BindingDB Entry DOI: 10.7270/Q2WD43MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
VHL complex (Homo sapiens (Human)) | BDBM454875 (US10730870, Example 38 | US11512083, Example 38) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ... | Citation and Details BindingDB Entry DOI: 10.7270/Q20K2DC4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
VHL complex (Homo sapiens (Human)) | BDBM454875 (US10730870, Example 38 | US11512083, Example 38) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 2.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ... | Citation and Details BindingDB Entry DOI: 10.7270/Q20K2DC4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
VHL complex (Homo sapiens (Human)) | BDBM454875 (US10730870, Example 38 | US11512083, Example 38) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 758 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ... | Citation and Details BindingDB Entry DOI: 10.7270/Q20K2DC4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM454875 (US10730870, Example 38 | US11512083, Example 38) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ... | US Patent US10730870 (2020) BindingDB Entry DOI: 10.7270/Q2WD43MN | |||||||||||
More data for this Ligand-Target Pair |