BDBM50013019 (S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydronaphthalen-1-ol::(S)-7-Dipropylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-ol::(S)-UH-301::7-Dipropylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-ol::7-Dipropylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-ol ((S)-UH301)::CHEMBL22778::UH-301
SMILES: CCCN(CCC)[C@H]1CCc2c(F)ccc(O)c2C1
InChI Key: InChIKey=FNKBVTBXFLSTPB-LBPRGKRZSA-N
Data: 20 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand | J Med Chem 39: 4036-43 (1996) Article DOI: 10.1021/jm960329o BindingDB Entry DOI: 10.7270/Q2XK8G6C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Binding affinity of the compound was evaluated against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand | J Med Chem 41: 2765-78 (1998) Article DOI: 10.1021/jm9707840 BindingDB Entry DOI: 10.7270/Q2K073CQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor | J Med Chem 40: 1252-7 (1997) Article DOI: 10.1021/jm960760d BindingDB Entry DOI: 10.7270/Q20R9Q26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor | J Med Chem 40: 1252-7 (1997) Article DOI: 10.1021/jm960760d BindingDB Entry DOI: 10.7270/Q20R9Q26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound towards 5-hydroxytryptamine 1A receptor sites in cortical membranes using [3H]-8-OH-DPAT as radioligand | J Med Chem 33: 1541-4 (1990) BindingDB Entry DOI: 10.7270/Q2QJ7G8P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 87 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Binding affinity was measured on cloned Human 5-hydroxytryptamine 1A receptor which is labeled by [3H]-8-OH-DPAT | J Med Chem 43: 1339-49 (2001) BindingDB Entry DOI: 10.7270/Q2RJ4HQ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound towards 5-hydroxytryptamine 1A receptor sites, in rat striatum membranes using [3H]- sandoz 205-501 as radioligand | J Med Chem 33: 1541-4 (1990) BindingDB Entry DOI: 10.7270/Q2QJ7G8P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 614 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description In vitro radioligand binding assay on Dopamine receptor D2 of rat striatum using [3H]- spiperone | J Med Chem 40: 1252-7 (1997) Article DOI: 10.1021/jm960760d BindingDB Entry DOI: 10.7270/Q20R9Q26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 614 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description In vitro radioligand binding assay on Dopamine receptor D2 of rat striatum using [3H]- spiperone | J Med Chem 40: 1252-7 (1997) Article DOI: 10.1021/jm960760d BindingDB Entry DOI: 10.7270/Q20R9Q26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 614 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Binding affinity of the compound was evaluated against Dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand; ND = Not determined | J Med Chem 41: 2765-78 (1998) Article DOI: 10.1021/jm9707840 BindingDB Entry DOI: 10.7270/Q2K073CQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DRD3 (pigeon) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNS-Pharmacology Curated by PDSP Ki Database | Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR3A (pigeon) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 2.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNS-Pharmacology Curated by PDSP Ki Database | Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 3.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]-5-HT | J Med Chem 43: 1339-49 (2001) BindingDB Entry DOI: 10.7270/Q2RJ4HQ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
adrenergic Alpha1 (pigeon) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 3.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNS-Pharmacology Curated by PDSP Ki Database | Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 3.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Binding affinity of the compound was measured on cloned Human D2A Receptor which is labeled by [3H]-Raclopride | J Med Chem 43: 1339-49 (2001) BindingDB Entry DOI: 10.7270/Q2RJ4HQ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DRD2 (pigeon) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 7.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNS-Pharmacology Curated by PDSP Ki Database | Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR2C (pigeon) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNS-Pharmacology Curated by PDSP Ki Database | Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR2A (pigeon) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNS-Pharmacology Curated by PDSP Ki Database | Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR1B (pigeon) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | PDB GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNS-Pharmacology Curated by PDSP Ki Database | Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR1D (pigeon) | BDBM50013019![]() ((S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydron...) | GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNS-Pharmacology Curated by PDSP Ki Database | Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM | ||||||||||||
More data for this Ligand-Target Pair |