BDBM102524 US8536175, 86

SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccccn2)c2ncc(nc12)N(C)CCN(C)C

InChI Key: InChIKey=MVSKVMADGSHVMB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 102524   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102524 (US8536175, 86) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccccn2)c2ncc(nc12)N(C)CCN(C)C |(8.09,-.67,;6.55,-.67,;5.78,.67,;6.55,2,;5.78,3.33,;6.55,4.67,;5.78,6,;4.23,3.33,;3.47,4.67,;3.47,2,;4.23,.67,;3.47,-.67,;1.93,2,;1.15,3.33,;-.38,3.33,;-1.15,2,;-2.69,2,;-3.47,3.33,;-3.47,.67,;-5,.67,;-5.78,2,;-7.31,2,;-8.08,.67,;-7.31,-.67,;-5.78,-.67,;-.38,.67,;-1.15,-.67,;-.38,-2,;1.15,-2,;1.93,-.67,;1.15,.67,;1.92,-3.33,;1.15,-4.67,;3.46,-3.33,;4.23,-4.67,;5.77,-4.67,;6.54,-6,;6.54,-3.33,)| Show InChI InChI=1S/C27H28Cl2N6O3/c1-34(2)12-13-35(3)21-15-31-25-17(27(36)32-20-8-6-7-11-30-20)10-9-16(26(25)33-21)22-23(28)18(37-4)14-19(38-5)24(22)29/h6-11,14-15H,12-13H2,1-5H3,(H,30,32,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.55E+3	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...				US Patent US8815901 (2014) BindingDB Entry DOI: 10.7270/Q2XG9PT8
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102524 (US8536175, 86) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccccn2)c2ncc(nc12)N(C)CCN(C)C |(8.09,-.67,;6.55,-.67,;5.78,.67,;6.55,2,;5.78,3.33,;6.55,4.67,;5.78,6,;4.23,3.33,;3.47,4.67,;3.47,2,;4.23,.67,;3.47,-.67,;1.93,2,;1.15,3.33,;-.38,3.33,;-1.15,2,;-2.69,2,;-3.47,3.33,;-3.47,.67,;-5,.67,;-5.78,2,;-7.31,2,;-8.08,.67,;-7.31,-.67,;-5.78,-.67,;-.38,.67,;-1.15,-.67,;-.38,-2,;1.15,-2,;1.93,-.67,;1.15,.67,;1.92,-3.33,;1.15,-4.67,;3.46,-3.33,;4.23,-4.67,;5.77,-4.67,;6.54,-6,;6.54,-3.33,)| Show InChI InChI=1S/C27H28Cl2N6O3/c1-34(2)12-13-35(3)21-15-31-25-17(27(36)32-20-8-6-7-11-30-20)10-9-16(26(25)33-21)22-23(28)18(37-4)14-19(38-5)24(22)29/h6-11,14-15H,12-13H2,1-5H3,(H,30,32,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Protein kinase activity measured by the microfluidic caliper method.				US Patent US8536175 (2013) BindingDB Entry DOI: 10.7270/Q27D2SSH
					More data for this Ligand-Target Pair