BDBM106561 US8586600, III-6
SMILES: CN(C)C\C=C\C(=O)Nc1ccc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc1C(F)(F)F
InChI Key: InChIKey=WIVJEMFJDXIPRD-FNORWQNLSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM106561 (US8586600, III-6) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Compounds may also be assayed as inhibitors of PDGFR in a manner substantially similar to the method described in Roberts, et al., Antiangiogen... | US Patent US8586600 (2013) BindingDB Entry DOI: 10.7270/Q2M61HWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM106561 (US8586600, III-6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Compounds may also be assayed as inhibitors of CKit in a manner substantially similar to the method described by Upstate (http://www.upstate.com/img/... | US Patent US8586600 (2013) BindingDB Entry DOI: 10.7270/Q2M61HWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM106561 (US8586600, III-6) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Compounds may be screened for their ability to inhibit KDR using a standard coupled enzyme assay (Fox et al., Protein Sci., (1998) 7, 2249). | US Patent US8586600 (2013) BindingDB Entry DOI: 10.7270/Q2M61HWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM106561 (US8586600, III-6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Compounds may also be assayed as inhibitors of CKit in a manner substantially similar to the method described by Upstate (http://www.upstate.com/img/... | US Patent US8586600 (2013) BindingDB Entry DOI: 10.7270/Q2M61HWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM106561 (US8586600, III-6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 216 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Compounds may also be assayed as inhibitors of CKit in a manner substantially similar to the method described by Upstate (http://www.upstate.com/img/... | US Patent US8586600 (2013) BindingDB Entry DOI: 10.7270/Q2M61HWH | |||||||||||
More data for this Ligand-Target Pair |