BDBM107704 US8598210, 119::US8598210, Table XV, 10::US8598210, Table XV, 11::US8722895, 10: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid trifluoroacetic acid salt::US8722895, 11: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid::US9598370, Example 00136::USRE47437, Example {[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acid
SMILES: OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
InChI Key: InChIKey=JGRXMPYUTJLTKT-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prolyl 4-hydroxylase (Paramecium bursaria Chlorella virus 1) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in... | Bioorg Med Chem 27: 2405-2412 (2019) Article DOI: 10.1016/j.bmc.2019.01.018 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl hydroxylase EGLN3 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight... | US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | 25 |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8722895 (2014) BindingDB Entry DOI: 10.7270/Q25Q4TRQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8722895 (2014) BindingDB Entry DOI: 10.7270/Q25Q4TRQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prolyl hydroxylase EGLN3 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | 25 |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8722895 (2014) BindingDB Entry DOI: 10.7270/Q25Q4TRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prolyl hydroxylase EGLN3 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight... | US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California at Los Angeles | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a |
University of California at Los Angeles | Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight... | Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California at Los Angeles | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prolyl hydroxylase EGLN3 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California at Los Angeles | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.37E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cadila Healthcare Limited Curated by ChEMBL | Assay Description Inhibition of HIF-PHD2 (unknown origin) expressed in insect Hi5 cells using peptide as substrate | J Med Chem 61: 6964-6982 (2018) Article DOI: 10.1021/acs.jmedchem.7b01686 BindingDB Entry DOI: 10.7270/Q2H70JC7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prolyl 3-hydroxylase OGFOD1 (Homo sapiens) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of recombinant human OGFOD1 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-a... | Bioorg Med Chem 27: 2405-2412 (2019) Article DOI: 10.1016/j.bmc.2019.01.018 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of recombinant human PHD2 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asc... | Bioorg Med Chem 27: 2405-2412 (2019) Article DOI: 10.1016/j.bmc.2019.01.018 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prolyl 4-hydroxylase (Paramecium bursaria Chlorella virus 1) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in... | Bioorg Med Chem 27: 2405-2412 (2019) Article DOI: 10.1016/j.bmc.2019.01.018 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hypoxia-inducible factor 1 (FIH) (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of recombinant human FIH using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asco... | Bioorg Med Chem 27: 2405-2412 (2019) Article DOI: 10.1016/j.bmc.2019.01.018 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107704 (US8598210, 119 | US8598210, Table XV, 10 | US85982...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |