BDBM107797 US8598155, 34

SMILES: Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cc2F)c2c(ncnn12)N1CCC1

InChI Key: InChIKey=VCDUPFPCYAYAPL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 107797   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM107797 (US8598155, 34) Show SMILES Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cc2F)c2c(ncnn12)N1CCC1 |(-.46,-3.97,;-1.23,-2.64,;-.32,-1.39,;-1.23,-.15,;-.46,1.19,;-1.36,2.43,;-.46,3.68,;1.01,3.2,;2.34,3.97,;1.01,1.66,;2.09,.57,;1.7,-.91,;2.78,-2,;4.27,-1.6,;5.36,-2.69,;4.67,-.12,;3.58,.97,;3.98,2.46,;-2.69,-.62,;-4.03,.15,;-5.36,-.62,;-5.36,-2.16,;-4.03,-2.93,;-2.69,-2.16,;-4.03,1.69,;-2.94,2.78,;-4.03,3.86,;-5.12,2.78,)| Show InChI InChI=1S/C19H17ClFN7/c1-11-25-16(18-19(27-6-3-7-27)22-10-24-28(11)18)14-9-23-26(2)17(14)13-5-4-12(20)8-15(13)21/h4-5,8-10H,3,6-7H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...				US Patent US8598155 (2013) BindingDB Entry DOI: 10.7270/Q26T0K8C
					More data for this Ligand-Target Pair