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SMILES: CC(C)(C)OC(=O)N[C@@H]1CN[C@@H](C1)C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N

InChI Key: InChIKey=QOIMMXHELQXMLS-MOLYVOAJSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 11923   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dipeptidyl peptidase 4


(Sus scrofa (pig))		BDBM11923
PNG
(substituted diprolyl nitrile 16 | tert-butyl N-[(3...)
Show SMILES CC(C)(C)OC(=O)N[C@@H]1CN[C@@H](C1)C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N |r|
Show InChI InChI=1S/C16H24N4O3/c1-16(2,3)23-15(22)19-10-6-12(18-8-10)14(21)20-11(7-17)4-9-5-13(9)20/h9-13,18H,4-6,8H2,1-3H3,(H,19,22)/t9-,10+,11+,12+,13+/m1/s1
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Similars
Article
PubMed
 140 -9.25n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...

Bioorg Med Chem Lett 15: 3992-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.043
BindingDB Entry DOI: 10.7270/Q2CN7259
More data for this
Ligand-Target Pair