BDBM119666 US8680275, 38

SMILES: CN(C)c1nc(cc(n1)C(F)(F)F)N1CC2CCN(CC12)C(=O)c1ccc(F)cc1-n1nccn1

InChI Key: InChIKey=JHGJXSYUJSBXDY-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119666   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM119666 (US8680275, 38) Show SMILES CN(C)c1nc(cc(n1)C(F)(F)F)N1CC2CCN(CC12)C(=O)c1ccc(F)cc1-n1nccn1 Show InChI InChI=1S/C22H22F4N8O/c1-31(2)21-29-18(22(24,25)26)10-19(30-21)33-11-13-5-8-32(12-17(13)33)20(35)15-4-3-14(23)9-16(15)34-27-6-7-28-34/h3-4,6-7,9-10,13,17H,5,8,11-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	16	-9.88	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM119666 (US8680275, 38) Show SMILES CN(C)c1nc(cc(n1)C(F)(F)F)N1CC2CCN(CC12)C(=O)c1ccc(F)cc1-n1nccn1 Show InChI InChI=1S/C22H22F4N8O/c1-31(2)21-29-18(22(24,25)26)10-19(30-21)33-11-13-5-8-32(12-17(13)33)20(35)15-4-3-14(23)9-16(15)34-27-6-7-28-34/h3-4,6-7,9-10,13,17H,5,8,11-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	77	-9.01	n/a	n/a	n/a	n/a	n/a	n/a	4
Janssen Pharmaceutica NV US Patent					Assay Description Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM 001526) were grown to confluency in DMEM/F12 (Gibco...				US Patent US8680275 (2014) BindingDB Entry DOI: 10.7270/Q2WH2NPF
					More data for this Ligand-Target Pair