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BDBM12034 3-(4-chlorophenyl)-1-{4-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]phenyl}urea::Phenylurenyl Chalcone deriv. 24

SMILES: Clc1ccc(NC(=O)Nc2ccc(cc2)C(=O)\C=C\c2ccc(Cl)cc2)cc1

InChI Key: InChIKey=FNXMFQXYWREPFS-LZWSPWQCSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 12034   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Falcipain-2


(Plasmodium falciparum)
BDBM12034
PNG
(3-(4-chlorophenyl)-1-{4-[(2E)-3-(4-chlorophenyl)pr...)
Show SMILES Clc1ccc(NC(=O)Nc2ccc(cc2)C(=O)\C=C\c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C22H16Cl2N2O2/c23-17-6-1-15(2-7-17)3-14-21(27)16-4-10-19(11-5-16)25-22(28)26-20-12-8-18(24)9-13-20/h1-14H,(H2,25,26,28)/b14-3+
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.60E+3n/an/an/an/a5.522



Universidad Central de Venezuela



Assay Description
The substrate peptide terminating in AMC is processed by falcipain-2 with or without inhibitors, and the accumulation of AMC was monitored in a Labsy...


J Med Chem 48: 3654-8 (2005)


Article DOI: 10.1021/jm058208o
BindingDB Entry DOI: 10.7270/Q2GF0RRD
More data for this
Ligand-Target Pair