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BDBM12340 3-{[(E)-({4-amino-6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]pyrimidin-5-yl}methylidene)amino]oxy}propan-1-ol::oxime analog 29

SMILES: Cc1cc2c(F)c(Oc3ncnc(N)c3\C=N\OCCCO)ccc2[nH]1

InChI Key: InChIKey=PJLXIULWTYKMBC-GZIVZEMBSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 12340   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
VEGFR-2 (KDR)


(Rattus norvegicus (rat))		BDBM12340
PNG
(3-{[(E)-({4-amino-6-[(4-fluoro-2-methyl-1H-indol-5...)
Show SMILES Cc1cc2c(F)c(Oc3ncnc(N)c3\C=N\OCCCO)ccc2[nH]1
Show InChI InChI=1S/C17H18FN5O3/c1-10-7-11-13(23-10)3-4-14(15(11)18)26-17-12(16(19)20-9-21-17)8-22-25-6-2-5-24/h3-4,7-9,23-24H,2,5-6H2,1H3,(H2,19,20,21)/b22-8+
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Similars
Article
PubMed
n/an/a 11n/an/an/an/a8.030



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...

Bioorg Med Chem Lett 16: 6063-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.107
BindingDB Entry DOI: 10.7270/Q28P5XRX
More data for this
Ligand-Target Pair