BDBM127672 US8791123, 45

SMILES: NS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F

InChI Key: InChIKey=AMZHEDMUKHBPBM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127672   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127672 (US8791123, 45) Show SMILES NS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F Show InChI InChI=1S/C22H25F2N7O3S/c23-14-3-4-18(24)16(12-14)19-2-1-8-30(19)20-7-11-31-21(28-20)17(13-26-31)22(32)27-15-5-9-29(10-6-15)35(25,33)34/h3-4,7,11-13,15,19H,1-2,5-6,8-10H2,(H,27,32)(H2,25,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	195	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127672 (US8791123, 45) Show SMILES NS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F Show InChI InChI=1S/C22H25F2N7O3S/c23-14-3-4-18(24)16(12-14)19-2-1-8-30(19)20-7-11-31-21(28-20)17(13-26-31)22(32)27-15-5-9-29(10-6-15)35(25,33)34/h3-4,7,11-13,15,19H,1-2,5-6,8-10H2,(H,27,32)(H2,25,33,34)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair