Found 18 hits for monomerid = 127677 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.23 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Array Biopharma, Inc.
US Patent
| Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
US Patent US8791123 (2014)
BindingDB Entry DOI: 10.7270/Q2Q23XX7 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB MMDB
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 186 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix... |
US Patent US10758542 (2020)
|
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.23 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
US Patent US9782415 (2017)
BindingDB Entry DOI: 10.7270/Q2P84F0G |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 418 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US9782415 (2017)
BindingDB Entry DOI: 10.7270/Q2P84F0G |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.18 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
US Patent US9782415 (2017)
BindingDB Entry DOI: 10.7270/Q2P84F0G |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 186 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US9782415 (2017)
BindingDB Entry DOI: 10.7270/Q2P84F0G |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.23 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital
| Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c... |
J Med Chem 50: 1876-85 (2007)
BindingDB Entry DOI: 10.7270/Q2R49T22 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 418 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital
| Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
J Med Chem 50: 1876-85 (2007)
BindingDB Entry DOI: 10.7270/Q2R49T22 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.18 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital
| Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c... |
J Med Chem 50: 1876-85 (2007)
BindingDB Entry DOI: 10.7270/Q2R49T22 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 186 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital
| Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
J Med Chem 50: 1876-85 (2007)
BindingDB Entry DOI: 10.7270/Q2R49T22 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.23 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an... |
US Patent US9796724 (2017)
BindingDB Entry DOI: 10.7270/Q27M0B21 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.18 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an... |
US Patent US9796724 (2017)
BindingDB Entry DOI: 10.7270/Q27M0B21 |
More data for this Ligand-Target Pair | |
JAK2 (aa 808-1132)
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 418 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US9796724 (2017)
BindingDB Entry DOI: 10.7270/Q27M0B21 |
More data for this Ligand-Target Pair | |
JAK2 (aa 808-1132)
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 186 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US9796724 (2017)
BindingDB Entry DOI: 10.7270/Q27M0B21 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.23 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
US Patent US10758542 (2020)
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB MMDB
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 418 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix... |
US Patent US10758542 (2020)
|
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.18 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
US Patent US10758542 (2020)
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM127677
(US10251889, Example 51 | US10758542, Example 51 | ...)Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| Show InChI InChI=1S/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 418 | n/a | n/a | n/a | n/a | n/a | n/a |
Array Biopharma, Inc.
US Patent
| Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c... |
US Patent US8791123 (2014)
BindingDB Entry DOI: 10.7270/Q2Q23XX7 |
More data for this Ligand-Target Pair | |