Reaction Details | |||
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Target | Tyrosine-protein kinase JAK2 [808-1132] | ||
Ligand | BDBM127677 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Jak2 Inhibition Assay | ||
IC50 | 418±n/a nM | ||
Citation | Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent US9796724 Publication Date 10/24/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK2 [808-1132] | |||
Name: | Tyrosine-protein kinase JAK2 [808-1132] | ||
Synonyms: | JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132) | ||
Type: | Protein | ||
Mol. Mass.: | 39171.39 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60674[808-1132] | ||
Residue: | 335 | ||
Sequence: |
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BDBM127677 | |||
n/a | |||
Name | BDBM127677 | ||
Synonyms: | US10251889, Example 51 | US10758542, Example 51 | US8791123, 50 | US9782415, Example 51 | US9796724, Example 51 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H27F2N5O2 | ||
Mol. Mass. | 455.5003 | ||
SMILES | C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r,w:8.8,wU:1.0,wD:24.28,1.1,(7.04,-6.19,;5.95,-5.1,;5.55,-6.59,;4.46,-4.7,;4.06,-3.21,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;4.75,-.64,;3.27,-.24,;2.18,-1.33,;2.87,1.25,;3.77,2.5,;2.87,3.74,;1.4,3.27,;.07,4.04,;-1.26,3.27,;-1.26,1.73,;.07,.96,;1.4,1.73,;-2.6,.96,;-2.6,-.58,;-4.06,-1.06,;-4.97,.19,;-4.06,1.43,;-4.46,2.92,;-3.37,4.01,;-3.77,5.5,;-2.68,6.59,;-5.26,5.9,;-6.35,4.81,;-5.95,3.32,;-7.04,2.23,)| | ||
Structure |