null

SMILES: COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCCC3)[nH]2)c2nccnc12

InChI Key: InChIKey=HSAFDFXWTBBRBK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130075   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM130075 (US8815901, 93) Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCCC3)[nH]2)c2nccnc12 |(10.31,-2.67,;8.77,-2.67,;8,-1.33,;8.77,,;8,1.33,;8.77,2.67,;8,4,;6.46,1.33,;5.69,2.67,;5.69,,;6.46,-1.33,;5.69,-2.67,;4.15,,;3.38,1.33,;1.84,1.33,;1.07,,;-.47,,;-1.24,1.33,;-1.24,-1.33,;-2.78,-1.33,;-3.69,-.09,;-5.15,-.56,;-5.15,-2.1,;-6.48,-2.87,;-7.82,-2.1,;-8.29,-.64,;-9.83,-.64,;-10.31,-2.1,;-9.06,-3.01,;-3.69,-2.58,;1.84,-1.33,;1.07,-2.67,;1.84,-4,;3.38,-4,;4.15,-2.67,;3.38,-1.33,)| Show InChI InChI=1S/C25H24F2N6O3/c1-35-17-11-18(36-2)21(27)19(20(17)26)15-5-6-16(23-22(15)28-7-8-29-23)24(34)32-25-30-12-14(31-25)13-33-9-3-4-10-33/h5-8,11-12H,3-4,9-10,13H2,1-2H3,(H2,30,31,32,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...				US Patent US8815901 (2014) BindingDB Entry DOI: 10.7270/Q2XG9PT8
					More data for this Ligand-Target Pair