BDBM136651 US10005783, 68::US10047097, 68::US10774085, Example 68::US8865698, 68::US9676783, 68

SMILES: Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1

InChI Key: InChIKey=OHIHEIPCEBOBSX-LJQANCHMSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 136651   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136651 (US10005783, 68 | US10047097, 68 | US10774085, Exam...) Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1 |r| Show InChI InChI=1S/C22H19FN6O/c23-16-6-3-5-15(13-16)19-8-4-11-28(19)20-9-12-29-21(27-20)18(14-25-29)26-22(30)17-7-1-2-10-24-17/h1-3,5-7,9-10,12-14,19H,4,8,11H2,(H,26,30)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8865698 (2014) BindingDB Entry DOI: 10.7270/Q2B856TM
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136651 (US10005783, 68 | US10047097, 68 | US10774085, Exam...) Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1 |r| Show InChI InChI=1S/C22H19FN6O/c23-16-6-3-5-15(13-16)19-8-4-11-28(19)20-9-12-29-21(27-20)18(14-25-29)26-22(30)17-7-1-2-10-24-17/h1-3,5-7,9-10,12-14,19H,4,8,11H2,(H,26,30)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10047097 (2018) BindingDB Entry DOI: 10.7270/Q2000442
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136651 (US10005783, 68 | US10047097, 68 | US10774085, Exam...) Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1 |r| Show InChI InChI=1S/C22H19FN6O/c23-16-6-3-5-15(13-16)19-8-4-11-28(19)20-9-12-29-21(27-20)18(14-25-29)26-22(30)17-7-1-2-10-24-17/h1-3,5-7,9-10,12-14,19H,4,8,11H2,(H,26,30)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10774085 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136651 (US10005783, 68 | US10047097, 68 | US10774085, Exam...) Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1 |r| Show InChI InChI=1S/C22H19FN6O/c23-16-6-3-5-15(13-16)19-8-4-11-28(19)20-9-12-29-21(27-20)18(14-25-29)26-22(30)17-7-1-2-10-24-17/h1-3,5-7,9-10,12-14,19H,4,8,11H2,(H,26,30)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM136651 (US10005783, 68 | US10047097, 68 | US10774085, Exam...) Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1 |r| Show InChI InChI=1S/C22H19FN6O/c23-16-6-3-5-15(13-16)19-8-4-11-28(19)20-9-12-29-21(27-20)18(14-25-29)26-22(30)17-7-1-2-10-24-17/h1-3,5-7,9-10,12-14,19H,4,8,11H2,(H,26,30)/t19-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma, Inc. US Patent					Assay Description Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...				US Patent US9676783 (2017) BindingDB Entry DOI: 10.7270/Q26H4FK5
					More data for this Ligand-Target Pair