BDBM140140 US8901315, 273

SMILES: Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1C(=O)CCC1=O

InChI Key: InChIKey=CKUHDWKGBHLZTA-WKILWMFISA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 140140   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 4 (PDE4) (Mus musculus (Mouse))	BDBM140140 (US8901315, 273) Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1C(=O)CCC1=O |r,wU:18.20,wD:21.27,(-6.96,3.48,;-6.19,2.14,;-7.1,.9,;-6.19,-.35,;-6.59,-1.84,;-8.08,-2.23,;-8.48,-3.72,;-7.39,-4.81,;-5.9,-4.41,;-5.5,-2.92,;-4.73,.13,;-3.27,-.35,;-2.36,.9,;-3.27,2.14,;-4.73,1.67,;-.82,.9,;-.05,-.44,;-.05,2.23,;1.49,2.23,;2.26,3.56,;3.8,3.56,;4.57,2.23,;3.8,.9,;2.26,.9,;6.11,2.23,;7.01,.99,;6.24,-.35,;8.48,1.46,;8.48,3,;7.01,3.48,;6.24,4.81,)| Show InChI InChI=1S/C23H30N4O3S/c1-14-18-13-19(31-23(18)27(25-14)17-5-3-2-4-6-17)22(30)24-15-7-9-16(10-8-15)26-20(28)11-12-21(26)29/h13,15-17H,2-12H2,1H3,(H,24,30)/t15-,16-	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	6.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 4 (phosphodiesterase IV) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifie...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair
Phosphodiesterase 7 (Homo sapiens (Human))	BDBM140140 (US8901315, 273) Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1C(=O)CCC1=O |r,wU:18.20,wD:21.27,(-6.96,3.48,;-6.19,2.14,;-7.1,.9,;-6.19,-.35,;-6.59,-1.84,;-8.08,-2.23,;-8.48,-3.72,;-7.39,-4.81,;-5.9,-4.41,;-5.5,-2.92,;-4.73,.13,;-3.27,-.35,;-2.36,.9,;-3.27,2.14,;-4.73,1.67,;-.82,.9,;-.05,-.44,;-.05,2.23,;1.49,2.23,;2.26,3.56,;3.8,3.56,;4.57,2.23,;3.8,.9,;2.26,.9,;6.11,2.23,;7.01,.99,;6.24,-.35,;8.48,1.46,;8.48,3,;7.01,3.48,;6.24,4.81,)| Show InChI InChI=1S/C23H30N4O3S/c1-14-18-13-19(31-23(18)27(25-14)17-5-3-2-4-6-17)22(30)24-15-7-9-16(10-8-15)26-20(28)11-12-21(26)29/h13,15-17H,2-12H2,1H3,(H,24,30)/t15-,16-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair