BDBM141032 US10570123, Example 243::US8916576, 243

SMILES: CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3n(C)ncc3c2)c2cc(OCCN(C)C)ccc2n1

InChI Key: InChIKey=QEQGYYKHVSFREH-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 141032   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141032 (US10570123, Example 243 | US8916576, 243) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3n(C)ncc3c2)c2cc(OCCN(C)C)ccc2n1 Show InChI InChI=1S/C30H33N7O2/c1-5-7-28(38)32-22-9-6-8-20(16-22)29-34-26-12-11-24(39-15-14-36(2)3)18-25(26)30(35-29)33-23-10-13-27-21(17-23)19-31-37(27)4/h6,8-13,16-19H,5,7,14-15H2,1-4H3,(H,32,38)(H,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>300	n/a	n/a	n/a	n/a	n/a	n/a
Surface Logix, Inc. US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US8916576 (2014) BindingDB Entry DOI: 10.7270/Q2P55M6K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141032 (US10570123, Example 243 | US8916576, 243) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3n(C)ncc3c2)c2cc(OCCN(C)C)ccc2n1 Show InChI InChI=1S/C30H33N7O2/c1-5-7-28(38)32-22-9-6-8-20(16-22)29-34-26-12-11-24(39-15-14-36(2)3)18-25(26)30(35-29)33-23-10-13-27-21(17-23)19-31-37(27)4/h6,8-13,16-19H,5,7,14-15H2,1-4H3,(H,32,38)(H,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
SURFACE LOGIX, LLC US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US10570123 (2020) BindingDB Entry DOI: 10.7270/Q2542R1V
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141032 (US10570123, Example 243 | US8916576, 243) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3n(C)ncc3c2)c2cc(OCCN(C)C)ccc2n1 Show InChI InChI=1S/C30H33N7O2/c1-5-7-28(38)32-22-9-6-8-20(16-22)29-34-26-12-11-24(39-15-14-36(2)3)18-25(26)30(35-29)33-23-10-13-27-21(17-23)19-31-37(27)4/h6,8-13,16-19H,5,7,14-15H2,1-4H3,(H,32,38)(H,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>300	n/a	n/a	n/a	n/a	n/a	n/a
SURFACE LOGIX, LLC US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US10570123 (2020) BindingDB Entry DOI: 10.7270/Q2542R1V
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141032 (US10570123, Example 243 | US8916576, 243) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3n(C)ncc3c2)c2cc(OCCN(C)C)ccc2n1 Show InChI InChI=1S/C30H33N7O2/c1-5-7-28(38)32-22-9-6-8-20(16-22)29-34-26-12-11-24(39-15-14-36(2)3)18-25(26)30(35-29)33-23-10-13-27-21(17-23)19-31-37(27)4/h6,8-13,16-19H,5,7,14-15H2,1-4H3,(H,32,38)(H,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Surface Logix, Inc. US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US8916576 (2014) BindingDB Entry DOI: 10.7270/Q2P55M6K
					More data for this Ligand-Target Pair