BDBM14393 5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(1-ethylazetidin-3-yl)-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::5-(5-Acetyl-2-butoxy-3-pyridinyl)-3-ethyl-2-(1-ethyl-3-azetidinyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::Sildenafil 5-methyl ketone analogue 2
SMILES: CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(CC)C1)C(C)=O
InChI Key: InChIKey=INLBUQIADGPECI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase Type 6 (PDE6) (Canis lupus familiaris (Dog)) | BDBM14393 (5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(1-eth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 840 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-... | J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM14393 (5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(1-eth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-... | J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |