BDBM145824 US8952177, 180::US8952177, 182::US9089569, 182::US9695149, 182

SMILES: CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(cc1)N1CCC(C)CC1)C(O)=O

InChI Key: InChIKey=JCDOBRTUVRFQGV-UHFFFAOYSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 145824   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145824 (US8952177, 180 | US8952177, 182 | US9089569, 182 |...) Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(cc1)N1CCC(C)CC1)C(O)=O Show InChI InChI=1S/C34H41FN4O3/c1-5-34(6-2,33(40)41)19-32-37-29-12-11-27(42-22-30-28(35)17-24(4)20-36-30)18-31(29)39(32)21-25-7-9-26(10-8-25)38-15-13-23(3)14-16-38/h7-12,17-18,20,23H,5-6,13-16,19,21-22H2,1-4H3,(H,40,41)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145824 (US8952177, 180 | US8952177, 182 | US9089569, 182 |...) Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(cc1)N1CCC(C)CC1)C(O)=O Show InChI InChI=1S/C34H41FN4O3/c1-5-34(6-2,33(40)41)19-32-37-29-12-11-27(42-22-30-28(35)17-24(4)20-36-30)18-31(29)39(32)21-25-7-9-26(10-8-25)38-15-13-23(3)14-16-38/h7-12,17-18,20,23H,5-6,13-16,19,21-22H2,1-4H3,(H,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145824 (US8952177, 180 | US8952177, 182 | US9089569, 182 |...) Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(cc1)N1CCC(C)CC1)C(O)=O Show InChI InChI=1S/C34H41FN4O3/c1-5-34(6-2,33(40)41)19-32-37-29-12-11-27(42-22-30-28(35)17-24(4)20-36-30)18-31(29)39(32)21-25-7-9-26(10-8-25)38-15-13-23(3)14-16-38/h7-12,17-18,20,23H,5-6,13-16,19,21-22H2,1-4H3,(H,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145824 (US8952177, 180 | US8952177, 182 | US9089569, 182 |...) Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(cc1)N1CCC(C)CC1)C(O)=O Show InChI InChI=1S/C34H41FN4O3/c1-5-34(6-2,33(40)41)19-32-37-29-12-11-27(42-22-30-28(35)17-24(4)20-36-30)18-31(29)39(32)21-25-7-9-26(10-8-25)38-15-13-23(3)14-16-38/h7-12,17-18,20,23H,5-6,13-16,19,21-22H2,1-4H3,(H,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145824 (US8952177, 180 | US8952177, 182 | US9089569, 182 |...) Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(cc1)N1CCC(C)CC1)C(O)=O Show InChI InChI=1S/C34H41FN4O3/c1-5-34(6-2,33(40)41)19-32-37-29-12-11-27(42-22-30-28(35)17-24(4)20-36-30)18-31(29)39(32)21-25-7-9-26(10-8-25)38-15-13-23(3)14-16-38/h7-12,17-18,20,23H,5-6,13-16,19,21-22H2,1-4H3,(H,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145824 (US8952177, 180 | US8952177, 182 | US9089569, 182 |...) Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(cc1)N1CCC(C)CC1)C(O)=O Show InChI InChI=1S/C34H41FN4O3/c1-5-34(6-2,33(40)41)19-32-37-29-12-11-27(42-22-30-28(35)17-24(4)20-36-30)18-31(29)39(32)21-25-7-9-26(10-8-25)38-15-13-23(3)14-16-38/h7-12,17-18,20,23H,5-6,13-16,19,21-22H2,1-4H3,(H,40,41)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair