BDBM150604 US10238633, Example 278::US8987249, 278::US9713606, 278
SMILES: CN(C)CCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
InChI Key: InChIKey=AWNMFDZAZNAOSJ-GIRPNKPCSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase I (Homo sapiens (Human)) | BDBM150604 (US10238633, Example 278 | US8987249, 278 | US97136...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cys... | US Patent US8987249 (2015) BindingDB Entry DOI: 10.7270/Q2KP80WG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase I (Homo sapiens (Human)) | BDBM150604 (US10238633, Example 278 | US8987249, 278 | US97136...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 6.0 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod.... | US Patent US9713606 (2017) BindingDB Entry DOI: 10.7270/Q21G0P8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin K (Homo sapiens (Human)) | BDBM150604 (US10238633, Example 278 | US8987249, 278 | US97136...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description To activate the proenzyme, 5 μl procathepsin K were mixed with 1 ul activation buffer, and incubated at room temperature for 30 min.5 μL te... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q22R3TZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase I (Homo sapiens (Human)) | BDBM150604 (US10238633, Example 278 | US8987249, 278 | US97136...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in a 1:2 ratio with ... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q22R3TZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin K (Homo sapiens (Human)) | BDBM150604 (US10238633, Example 278 | US8987249, 278 | US97136...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | 3.5 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr... | US Patent US9713606 (2017) BindingDB Entry DOI: 10.7270/Q21G0P8M | |||||||||||
More data for this Ligand-Target Pair |