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BDBM151469 US8987314, B280

SMILES: CC(C)S(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2c(F)cc(cc2s1)-c1cccc(c1)C(=O)OC(C)(C)C

InChI Key: InChIKey=BMQWCACNEMPCGT-UHFFFAOYNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151469   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151469
PNG
(US8987314, B280)
Show SMILES CC(C)S(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2c(F)cc(cc2s1)-c1cccc(c1)C(=O)OC(C)(C)C
Show InChI InChI=1/C25H30FN3O7S3/c1-14(2)39(34,35)21(22(30)28-9-10-38(27,32)33)23-29-20-18(26)12-17(13-19(20)37-23)15-7-6-8-16(11-15)24(31)36-25(3,4)5/h6-8,11-14,21H,9-10H2,1-5H3,(H,28,30)(H2,27,32,33)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.90n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151469
PNG
(US8987314, B280)
Show SMILES CC(C)S(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2c(F)cc(cc2s1)-c1cccc(c1)C(=O)OC(C)(C)C
Show InChI InChI=1/C25H30FN3O7S3/c1-14(2)39(34,35)21(22(30)28-9-10-38(27,32)33)23-29-20-18(26)12-17(13-19(20)37-23)15-7-6-8-16(11-15)24(31)36-25(3,4)5/h6-8,11-14,21H,9-10H2,1-5H3,(H,28,30)(H2,27,32,33)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.80n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair