BDBM15152 1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyrazin-2-yl)phenyl]methyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one::pyrazinone 13b

SMILES: Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1

InChI Key: InChIKey=VQEYGNWUFJMZPZ-UHFFFAOYSA-N

Data: 1 KI  4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 15152   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15152 (1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...) Show SMILES Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(22-7-3-2-4-8-22)27(31-20)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	760	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California-San Francisco Curated by ChEMBL					Assay Description Inhibition of Akt1				Chem Biol 12: 621-37 (2005) Article DOI: 10.1016/j.chembiol.2005.04.011 BindingDB Entry DOI: 10.7270/Q2R49RR6
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM15152 (1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...) Show SMILES Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(22-7-3-2-4-8-22)27(31-20)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15152 (1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...) Show SMILES Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(22-7-3-2-4-8-22)27(31-20)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of Akt				Eur J Med Chem 44: 4090-7 (2009) Article DOI: 10.1016/j.ejmech.2009.04.050 BindingDB Entry DOI: 10.7270/Q2GT5N74
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15152 (1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...) Show SMILES Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(22-7-3-2-4-8-22)27(31-20)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM15152 (1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...) Show SMILES Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(22-7-3-2-4-8-22)27(31-20)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...				Bioorg Med Chem Lett 15: 761-4 (2005) Article DOI: 10.1016/j.bmcl.2004.11.011 BindingDB Entry DOI: 10.7270/Q2TX3CM4
					More data for this Ligand-Target Pair