BDBM153684 US10507215, Compound 1::US9000015, 1::US9610299, Example 1
SMILES: COCCOc1cc(Cl)c(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c(Cl)c1
InChI Key: InChIKey=LHRZBKAEDZUYNC-UHFFFAOYSA-N
Data: 9 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM153684 (US10507215, Compound 1 | US9000015, 1 | US9610299,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.30E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Gilead Sciences, Inc. US Patent | Assay Description MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with eserase. Standard MAO reactio... | US Patent US9000015 (2015) BindingDB Entry DOI: 10.7270/Q28S4NNX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldehyde dehydrogenase, mitochondrial (Homo sapiens (Human)) | BDBM153684 (US10507215, Compound 1 | US9000015, 1 | US9610299,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 63 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Gilead Sciences, Inc. US Patent | Assay Description Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ... | US Patent US9000015 (2015) BindingDB Entry DOI: 10.7270/Q28S4NNX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM153684 (US10507215, Compound 1 | US9000015, 1 | US9610299,...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.30E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Gilead Sciences, Inc. US Patent | Assay Description MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with eserase. Standard MAO reactio... | US Patent US9000015 (2015) BindingDB Entry DOI: 10.7270/Q28S4NNX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldehyde dehydrogenase, mitochondrial (Homo sapiens (Human)) | BDBM153684 (US10507215, Compound 1 | US9000015, 1 | US9610299,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ... | US Patent US9610299 (2017) BindingDB Entry DOI: 10.7270/Q2FQ9ZPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM153684 (US10507215, Compound 1 | US9000015, 1 | US9610299,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amygdala Neurosciences, Inc. US Patent | Assay Description MAO assays included lumnuogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti... | US Patent US10507215 (2019) BindingDB Entry DOI: 10.7270/Q2FF3VRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM153684 (US10507215, Compound 1 | US9000015, 1 | US9610299,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti... | US Patent US9610299 (2017) BindingDB Entry DOI: 10.7270/Q2FQ9ZPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldehyde dehydrogenase, mitochondrial (Homo sapiens (Human)) | BDBM153684 (US10507215, Compound 1 | US9000015, 1 | US9610299,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Amygdala Neurosciences, Inc. US Patent | Assay Description Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ... | US Patent US10507215 (2019) BindingDB Entry DOI: 10.7270/Q2FF3VRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] A (Homo sapiens (Human)) | BDBM153684 (US10507215, Compound 1 | US9000015, 1 | US9610299,...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amygdala Neurosciences, Inc. US Patent | Assay Description MAO assays included lumnuogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti... | US Patent US10507215 (2019) BindingDB Entry DOI: 10.7270/Q2FF3VRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM153684 (US10507215, Compound 1 | US9000015, 1 | US9610299,...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti... | US Patent US9610299 (2017) BindingDB Entry DOI: 10.7270/Q2FQ9ZPV | |||||||||||
More data for this Ligand-Target Pair |