BDBM15378 9-butyl-8-(2,5-dimethoxybenzyl)-9H-purin-6-amine::9-butyl-8-[(2,5-dimethoxyphenyl)methyl]-9H-purin-6-amine::CHEMBL113194::PU7::Purine-Based Inhibitor 5
SMILES: CCCCn1c(Cc2cc(OC)ccc2OC)nc2c(N)ncnc12
InChI Key: InChIKey=PPFZLLAIQRZNJE-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer. 2 PDB IDs contain this monomer as substructures. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Heat Shock Protein 90 (Hsp90) (Saccharomyces cerevisiae) | BDBM15378 (9-butyl-8-(2,5-dimethoxybenzyl)-9H-purin-6-amine |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Vernalis (R&D) Ltd | Assay Description The HSP90 ATPase activity was determined by following the procedure of malachite green assay. The assay is based on quantitation of the green complex... | Chem Biol 11: 775-85 (2004) Article DOI: 10.1016/j.chembiol.2004.03.033 BindingDB Entry DOI: 10.7270/Q2RX99BC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat Shock Protein 90 (Hsp90) (Homo sapiens (Human)) | BDBM15378 (9-butyl-8-(2,5-dimethoxybenzyl)-9H-purin-6-amine |...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
RiboTargets Ltd Curated by ChEMBL | Assay Description Inhibition of ATP-ase activity in human colon tumour cell line (HCT116) | Bioorg Med Chem Lett 14: 325-8 (2003) BindingDB Entry DOI: 10.7270/Q2P55MX0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15378 (9-butyl-8-(2,5-dimethoxybenzyl)-9H-purin-6-amine |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 1.20E+4 | n/a | n/a | 7.2 | 37 |
Conforma Therapeutics Corporation | Assay Description EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam... | J Med Chem 49: 817-28 (2006) Article DOI: 10.1021/jm0503087 BindingDB Entry DOI: 10.7270/Q2BC3WT5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |